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  1. Research

    Inhaled ambient-level traffic-derived particulates decrease cardiac vagal influence and baroreflexes and increase arrhythmia in a rat model of metabolic syndrome

    Epidemiological studies have linked exposures to ambient fine particulate matter (PM2.5) and traffic with autonomic nervous system imbalance (ANS) and cardiac pathophysiology, especially in individuals with preex...

    Alex P. Carll, Samir M. Crespo, Mauricio S. Filho, Douglas H. Zati, Brent A. Coull, Edgar A. Diaz, Rodrigo D. Raimundo, Thomas N. G. Jaeger, Ana Laura Ricci-Vitor, Vasileios Papapostolou, Joy E. Lawrence, David M. Garner, Brigham S. Perry, Jack R. Harkema and John J. Godleski

    Particle and Fibre Toxicology 2017 14:16

    Published on: 25 May 2017

  2. Research

    Impaired lysosomal activity mediated autophagic flux disruption by graphite carbon nanofibers induce apoptosis in human lung epithelial cells through oxidative stress and energetic impairment

    Graphite carbon nanofibers (GCNF) have emerged as a potential alternative of carbon nanotubes (CNT) for various biomedical applications due to their superior physico-chemical properties. Therefore in-depth und...

    Sandeep Mittal, Pradeep Kumar Sharma, Ratnakar Tiwari, Raja Gopal Rayavarapu, Jai Shankar, Lalit Kumar Singh Chauhan and Alok Kumar Pandey

    Particle and Fibre Toxicology 2017 14:15

    Published on: 28 April 2017

  3. Research Article

    Reduction of pulmonary toxicity of metal oxide nanoparticles by phosphonate-based surface passivation

    The wide application of engineered nanoparticles has induced increasing exposure to humans and environment, which led to substantial concerns on their biosafety. Some metal oxides (MOx) have shown severe toxic...

    Xiaoming Cai, Anson Lee, Zhaoxia Ji, Cynthia Huang, Chong Hyun Chang, Xiang Wang, Yu-Pei Liao, Tian Xia and Ruibin Li

    Particle and Fibre Toxicology 2017 14:13

    Published on: 21 April 2017

  4. Research

    In vivo quantification of quantum dot systemic transport in C57BL/6 hairless mice following skin application post-ultraviolet radiation

    Previous work has demonstrated size, surface charge and skin barrier dependent penetration of nanoparticles into the viable layers of mouse skin. The goal of this work was to characterize the tissue distributi...

    Samreen Jatana, Brian C. Palmer, Sarah J. Phelan, Robert Gelein and Lisa A. DeLouise

    Particle and Fibre Toxicology 2017 14:12

    Published on: 14 April 2017

  5. Research

    Deposition efficiency of inhaled particles (15-5000 nm) related to breathing pattern and lung function: an experimental study in healthy children and adults

    Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations ha...

    Jenny Rissler, Anders Gudmundsson, Hanna Nicklasson, Erik Swietlicki, Per Wollmer and Jakob Löndahl

    Particle and Fibre Toxicology 2017 14:10

    Published on: 8 April 2017

  6. Research

    Biological effects of carbon black nanoparticles are changed by surface coating with polycyclic aromatic hydrocarbons

    Carbon black nanoparticles (CBNP) are mainly composed of carbon, with a small amount of other elements (including hydrogen and oxygen). The toxicity of CBNP has been attributed to their large surface area, and...

    Karina Lindner, Michael Ströbele, Sandra Schlick, Sina Webering, André Jenckel, Johannes Kopf, Olga Danov, Katherina Sewald, Christian Buj, Otto Creutzenberg, Thomas Tillmann, Gerhard Pohlmann, Heinrich Ernst, Christina Ziemann, Gereon Hüttmann, Holger Heine…

    Particle and Fibre Toxicology 2017 14:8

    Published on: 21 March 2017

  7. Research

    Endothelial responses of the alveolar barrier in vitro in a dose-controlled exposure to diesel exhaust particulate matter

    During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental partic...

    Sebastian G. Klein, Sébastien Cambier, Jennifer Hennen, Sylvain Legay, Tommaso Serchi, Inge Nelissen, Aline Chary, Elisa Moschini, Andreas Krein, Brunhilde Blömeke and Arno C. Gutleb

    Particle and Fibre Toxicology 2017 14:7

    Published on: 6 March 2017

  8. Research

    Particulate Air pollution mediated effects on insulin resistance in mice are independent of CCR2

    Chronic exposure to fine ambient particulate matter (PM2.5) induces insulin resistance. CC-chemokine receptor 2 (CCR2) appears to be essential in diet-induced insulin resistance implicating an important role for ...

    Cuiqing Liu, Xiaohua Xu, Yuntao Bai, Jixin Zhong, Aixia Wang, Lixian Sun, Liya Kong, Zhekang Ying, Qinghua Sun and Sanjay Rajagopalan

    Particle and Fibre Toxicology 2017 14:6

    Published on: 3 March 2017

  9. Research

    Slow lung clearance and limited translocation of four sizes of inhaled iridium nanoparticles

    Concerns have been expressed that inhaled nanoparticles may behave differently to larger particles in terms of lung clearance and translocation, with potential implications for their toxicity. Studies undertak...

    Alison Buckley, James Warren, Alan Hodgson, Tim Marczylo, Konstantin Ignatyev, Chang Guo and Rachel Smith

    Particle and Fibre Toxicology 2017 14:5

    Published on: 10 February 2017

  10. Research

    Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle

    Recent studies indicate that maternal exposure to ambient ultrafine particles and nanoparticles has adverse effects of on the central nervous system. Quantitative dose–response data is required to better under...

    Atsuto Onoda, Ken Takeda and Masakazu Umezawa

    Particle and Fibre Toxicology 2017 14:4

    Published on: 2 February 2017

  11. Research

    Prenatal and postnatal mothering by diesel exhaust PM2.5-exposed dams differentially program mouse energy metabolism

    Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cau...

    Minjie Chen, Shuai Liang, Huifen Zhou, Yanyi Xu, Xiaobo Qin, Ziying Hu, Xiaoke Wang, Lianglin Qiu, Wanjun Wang, Yuhao Zhang and Zhekang Ying

    Particle and Fibre Toxicology 2017 14:3

    Published on: 18 January 2017

  12. Research

    In vitro biological responses to nanofibrillated cellulose by human dermal, lung and immune cells: surface chemistry aspect

    Nanocellulose, and particularly nanofibrillated cellulose (NFC), has been proposed for a diversity of applications in industry and in the biomedical field. Its unique physicochemical and structural features di...

    Viviana R. Lopes, Carla Sanchez-Martinez, Maria Strømme and Natalia Ferraz

    Particle and Fibre Toxicology 2017 14:1

    Published on: 10 January 2017

  13. Research

    Nanoparticle exposure reactivates latent herpesvirus and restores a signature of acute infection

    Inhalation of environmental (nano) particles (NP) as well as persistent herpesvirus-infection are potentially associated with chronic lung disease and as both are omnipresent in human society a coincidence of ...

    Christine Sattler, Franco Moritz, Shanze Chen, Beatrix Steer, David Kutschke, Martin Irmler, Johannes Beckers, Oliver Eickelberg, Philippe Schmitt-Kopplin, Heiko Adler and Tobias Stoeger

    Particle and Fibre Toxicology 2017 14:2

    Published on: 10 January 2017

  14. Research

    Combined exposure of diesel exhaust particles and respirable Soufrière Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model

    There are justifiable health concerns regarding the potential adverse effects associated with human exposure to volcanic ash (VA) particles, especially when considering communities living in urban areas alread...

    Ines Tomašek, Claire J. Horwell, David E. Damby, Hana Barošová, Christoph Geers, Alke Petri-Fink, Barbara Rothen-Rutishauser and Martin J. D. Clift

    Particle and Fibre Toxicology 2016 13:67

    Published on: 12 December 2016

  15. Research

    Early kidney damage induced by subchronic exposure to PM2.5 in rats

    Particulate matter exposure is associated with respiratory and cardiovascular system dysfunction. Recently, we demonstrated that fine particles, also named PM2.5, modify the expression of some components of the a...

    O. G. Aztatzi-Aguilar, M. Uribe-Ramírez, J. Narváez-Morales, A. De Vizcaya-Ruiz and O. Barbier

    Particle and Fibre Toxicology 2016 13:68

    Published on: 12 December 2016

  16. Erratum

    Erratum to: Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing

    Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patricia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi and Pascal Colpo

    Particle and Fibre Toxicology 2016 13:66

    Published on: 9 December 2016

    The original article was published in Particle and Fibre Toxicology 2016 13:47

  17. Research

    Surface area-dependence of gas-particle interactions influences pulmonary and neuroinflammatory outcomes

    Deleterious consequences of exposure to traffic emissions may derive from interactions between carbonaceous particulate matter (PM) and gaseous components in a manner that is dependent on the surface area or c...

    Christina R. Tyler, Katherine E. Zychowski, Bethany N. Sanchez, Valeria Rivero, Selita Lucas, Guy Herbert, June Liu, Hammad Irshad, Jacob D. McDonald, Barry E. Bleske and Matthew J. Campen

    Particle and Fibre Toxicology 2016 13:64

    Published on: 1 December 2016

  18. Research

    Contrasting biological potency of particulate matter collected at sites impacted by distinct industrial sources

    Industrial sources contribute a significant proportion of anthropogenic particulate matter (PM) emissions, producing particles of varying composition that may differentially impact health. This study investiga...

    Errol M. Thomson, Dalibor Breznan, Subramanian Karthikeyan, Christine MacKinnon-Roy, Ngoc Q. Vuong, Ewa Dabek-Zlotorzynska, Valbona Celo, Jean-Pierre Charland, Prem Kumarathasan, Jeffrey R. Brook and Renaud Vincent

    Particle and Fibre Toxicology 2016 13:65

    Published on: 1 December 2016

  19. Research

    Endocytosed nanoparticles hold endosomes and stimulate binucleated cells formation

    Nanotechnology developed rapidly in cellular diagnosis and treatment, the endocytic system was an important pathway for targeting cell. In the research of developing macrophages as drug carriers or important t...

    Lin Xia, Weihong Gu, Mingyi Zhang, Ya-Nan Chang, Kui Chen, Xue Bai, Lai Yu, Juan Li, Shan Li and Gengmei Xing

    Particle and Fibre Toxicology 2016 13:63

    Published on: 29 November 2016

  20. Research

    Interaction of rat alveolar macrophages with dental composite dust

    Dental composites have become the standard filling material to restore teeth, but during the placement of these restorations, high amounts of respirable composite dust (<5 μm) including many nano-sized particl...

    K. L. Van Landuyt, S. M. Cokic, C. Asbach, P. Hoet, L. Godderis, F. X. Reichl, B. Van Meerbeek, A. Vennemann and M. Wiemann

    Particle and Fibre Toxicology 2016 13:62

    Published on: 26 November 2016

  21. Research

    Early signs of multi-walled carbon nanotbues degradation in macrophages, via an intracellular pH-dependent biological mechanism; importance of length and functionalization

    Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages...

    Marion Landry, Mathieu Pinault, Stéphane Tchankouo, Émeline Charon, Audrey Ridoux, Jorge Boczkowski, Martine Mayne-L’Hermite and Sophie Lanone

    Particle and Fibre Toxicology 2016 13:61

    Published on: 24 November 2016

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