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  1. Research

    Air-liquid interface exposure to aerosols of poorly soluble nanomaterials induces different biological activation levels compared to exposure to suspensions

    Recently, much progress has been made to develop more physiologic in vitro models of the respiratory system and improve in vitro simulation of particle exposure through inhalation. Nevertheless, the field of n...

    Thomas Loret, Emmanuel Peyret, Marielle Dubreuil, Olivier Aguerre-Chariol, Christophe Bressot, Olivier le Bihan, Tanguy Amodeo, Bénédicte Trouiller, Anne Braun, Christophe Egles and Ghislaine Lacroix

    Particle and Fibre Toxicology 2016 13:58

    Published on: 3 November 2016

  2. Research

    Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles

    Copper nanoparticles (Cu NPs) have great potential in electronics and biomedical fields because of their efficient thermodynamic and anti-microbial properties. However, their potential toxic effects and kineti...

    In-Chul Lee, Je-Won Ko, Sung-Hyeuk Park, Na-Rae Shin, In-Sik Shin, Changjong Moon, Je-Hein Kim, Hyoung-Chin Kim and Jong-Choon Kim

    Particle and Fibre Toxicology 2016 13:56

    Published on: 28 October 2016

  3. Research

    Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy

    Silicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced b...

    Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng, Yingming Zhang, Hong Liao, Honghong Yao and Jie Chao

    Particle and Fibre Toxicology 2016 13:55

    Published on: 25 October 2016

  4. Research

    Single- and double-walled carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction

    The use of carbon nanotubes has increased lately. However, the cardiovascular effect of exposure to carbon nanotubes remains elusive. The present study investigated the effects of pulmonary exposure to single-...

    Yuka Suzuki, Saeko Tada-Oikawa, Yasuhiko Hayashi, Kiyora Izuoka, Misa Kataoka, Shunsuke Ichikawa, Wenting Wu, Cai Zong, Gaku Ichihara and Sahoko Ichihara

    Particle and Fibre Toxicology 2016 13:54

    Published on: 13 October 2016

  5. Research

    Lung carcinogenicity of inhaled multi-walled carbon nanotube in rats

    Multi-walled carbon nanotubes (MWCNTs) constitute one of the most promising types of nanomaterials in industry today. With their increasing use, the potential toxicity and carcinogenicity of MWCNT needs to be ...

    Tatsuya Kasai, Yumi Umeda, Makoto Ohnishi, Takashi Mine, Hitomi Kondo, Tetsuya Takeuchi, Michiharu Matsumoto and Shoji Fukushima

    Particle and Fibre Toxicology 2016 13:53

    Published on: 13 October 2016

  6. Research

    The role of hypoxia-inducible factor-1α in zinc oxide nanoparticle-induced nephrotoxicity in vitro and in vivo

    Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of products, including rubber manufacture, cosmetics, pigments, food additives, medicine, chemical fibers and electronics. However, the molec...

    Yuh-Feng Lin, I-Jen Chiu, Fong-Yu Cheng, Yu-Hsuan Lee, Ying-Jan Wang, Yung-Ho Hsu and Hui-Wen Chiu

    Particle and Fibre Toxicology 2016 13:52

    Published on: 27 September 2016

  7. Research

    Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

    The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays de...

    John W. Wills, Nicole Hondow, Adam D. Thomas, Katherine E. Chapman, David Fish, Thierry G. Maffeis, Mark W. Penny, Richard A. Brown, Gareth J. S. Jenkins, Andy P. Brown, Paul A. White and Shareen H. Doak

    Particle and Fibre Toxicology 2016 13:50

    Published on: 9 September 2016

  8. Research

    Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

    The rapidly increasing number of engineered nanoparticles (NPs), and products containing NPs, raises concerns for human exposure and safety. With this increasing, and ever changing, catalogue of NPs it is beco...

    Matthew S. P. Boyles, Christina Ranninger, Roland Reischl, Marc Rurik, Richard Tessadri, Oliver Kohlbacher, Albert Duschl and Christian G. Huber

    Particle and Fibre Toxicology 2016 13:49

    Published on: 8 September 2016

  9. Research

    Impact of pulmonary exposure to gold core silver nanoparticles of different size and capping agents on cardiovascular injury

    The uses of engineered nanomaterials have expanded in biomedical technology and consumer manufacturing. Furthermore, pulmonary exposure to various engineered nanomaterials has, likewise, demonstrated the abili...

    Nathan A. Holland, Leslie C. Thompson, Achini K. Vidanapathirana, Rahkee N. Urankar, Robert M. Lust, Timothy R. Fennell and Christopher J. Wingard

    Particle and Fibre Toxicology 2016 13:48

    Published on: 24 August 2016

  10. Research

    Quantification of the cellular dose and characterization of nanoparticle transport during in vitro testing

    The constant increase of the use of nanomaterials in consumer products is making increasingly urgent that standardized and reliable in vitro test methods for toxicity screening be made available to the scienti...

    Grigore Rischitor, Mariantonietta Parracino, Rita La Spina, Patrizia Urbán, Isaac Ojea-Jiménez, Elena Bellido, Andrea Valsesia, Sabrina Gioria, Robin Capomaccio, Agnieszka Kinsner-Ovaskainen, Douglas Gilliland, François Rossi and Pascal Colpo

    Particle and Fibre Toxicology 2016 13:47

    Published on: 24 August 2016

    The Erratum to this article has been published in Particle and Fibre Toxicology 2016 13:66

  11. Research

    Mesothelioma response to carbon nanotubes is associated with an early and selective accumulation of immunosuppressive monocytic cells

    The asbestos-like toxicity of some engineered carbon nanotubes (CNT), notably their capacity to induce mesothelioma, is a serious cause of concern for public health. Here we show that carcinogenic CNT induce a...

    François Huaux, Virginie d’Ursel de Bousies, Marie-Astrid Parent, Micaela Orsi, Francine Uwambayinema, Raynal Devosse, Saloua Ibouraadaten, Yousof Yakoub, Nadtha Panin, Mihaly Palmai-Pallag, Pierre van der Bruggen, Christian Bailly, Riccardo Marega, Etienne Marbaix and Dominique Lison

    Particle and Fibre Toxicology 2016 13:46

    Published on: 23 August 2016

  12. Research

    In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats

    Cerium oxide (CeO2) nanoparticles used as a diesel fuel additive can be emitted into the ambient air leading to human inhalation. Although biological studies have shown CeO2 nanoparticles can cause adverse health...

    Dingsheng Li, Masako Morishita, James G. Wagner, Mohammad Fatouraie, Margaret Wooldridge, W. Ethan Eagle, James Barres, Ulrika Carlander, Claude Emond and Olivier Jolliet

    Particle and Fibre Toxicology 2016 13:45

    Published on: 20 August 2016

  13. Research

    Long-term exposure to commercially available sunscreens containing nanoparticles of TiO2 and ZnO revealed no biological impact in a hairless mouse model

    The application of sunscreen is a critical component of a sun-safe strategy, however the possibility of unexpected, adverse outcomes resulting from long-term use of sunscreens containing nanoparticles of titan...

    Megan J. Osmond-McLeod, Yalchin Oytam, Anthony Rowe, Fariborz Sobhanmanesh, Gavin Greenoak, Jason Kirby, Elizabeth F. McInnes and Maxine J. McCall

    Particle and Fibre Toxicology 2016 13:44

    Published on: 17 August 2016

  14. Research

    Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice

    Although classified as metal oxides, cobalt monoxide (CoO) and lanthanum oxide (La2O3) nanoparticles, as representative transition and rare earth oxides, exhibit distinct material properties that may result in di...

    Jennifer D. Sisler, Ruibin Li, Walter McKinney, Robert R. Mercer, Zhaoxia Ji, Tian Xia, Xiang Wang, Justine Shaffer, Marlene Orandle, Amy L. Mihalchik, Lori Battelli, Bean T. Chen, Michael Wolfarth, Michael E. Andrew, Diane Schwegler-Berry, Dale W. Porter…

    Particle and Fibre Toxicology 2016 13:42

    Published on: 15 August 2016

  15. Research

    Development of an integrated approach for comparison of in vitro and in vivo responses to particulate matter

    Association of particulate matter with adverse health effects has been established in epidemiological studies and animal experiments. Epidemiological studies are difficult to undertake while animal studies are...

    Dalibor Breznan, Subramanian Karthikeyan, Marcelle Phaneuf, Prem Kumarathasan, Sabit Cakmak, Michael S. Denison, Jeffrey R. Brook and Renaud Vincent

    Particle and Fibre Toxicology 2016 13:41

    Published on: 12 August 2016

  16. Research

    Maternal exposure to diluted diesel engine exhaust alters placental function and induces intergenerational effects in rabbits

    Airborne pollution is a rising concern in urban areas. Epidemiological studies in humans and animal experiments using rodent models indicate that gestational exposure to airborne pollution, in particular diese...

    Sarah A. Valentino, Anne Tarrade, Josiane Aioun, Eve Mourier, Christophe Richard, Michèle Dahirel, Delphine Rousseau-Ralliard, Natalie Fournier, Marie-Christine Aubrière, Marie-Sylvie Lallemand, Sylvaine Camous, Marine Guinot, Madia Charlier, Etienne Aujean, Hala Al Adhami, Paul H. Fokkens…

    Particle and Fibre Toxicology 2016 13:39

    Published on: 26 July 2016

  17. Research

    Dietary silver nanoparticles can disturb the gut microbiota in mice

    Humans are increasingly exposed via the diet to Ag nanoparticles (NP) used in the food industry. Because of their anti-bacterial activity, ingested Ag NP might disturb the gut microbiota that is essential for ...

    Sybille van den Brule, Jérôme Ambroise, Hélène Lecloux, Clément Levard, Romain Soulas, Pieter-Jan De Temmerman, Mihaly Palmai-Pallag, Etienne Marbaix and Dominique Lison

    Particle and Fibre Toxicology 2016 13:38

    Published on: 8 July 2016

  18. Research

    Epoxy composite dusts with and without carbon nanotubes cause similar pulmonary responses, but differences in liver histology in mice following pulmonary deposition

    The toxicity of dusts from mechanical abrasion of multi-walled carbon nanotube (CNT) epoxy nanocomposites is unknown. We compared the toxic effects of dusts generated by sanding of epoxy composites with and wi...

    Anne Thoustrup Saber, Alicja Mortensen, Józef Szarek, Ismo Kalevi Koponen, Marcus Levin, Nicklas Raun Jacobsen, Maria Elena Pozzebon, Stefano Pozzi Mucelli, David George Rickerby, Kirsten Kling, Rambabu Atluri, Anne Mette Madsen, Petra Jackson, Zdenka Orabi Kyjovska, Ulla Vogel, Keld Alstrup Jensen…

    Particle and Fibre Toxicology 2016 13:37

    Published on: 29 June 2016

  19. Research

    Titanium dioxide nanoparticles induce the expression of early and late receptors for adhesion molecules on monocytes

    There is growing evidence that exposure to titanium dioxide nanoparticles (TiO2 NPs) could be harmful. Previously, we have shown that TiO2 NPs induces endothelial cell dysfunction and damage in glial cells. Consi...

    Cristhiam Rueda-Romero, Guillermina Hernández-Pérez, Pilar Ramos-Godínez, Inés Vázquez-López, Raúl Omar Quintana-Belmares, Elizabeth Huerta-García, Ewa Stepien, Rebeca López-Marure, Angélica Montiel-Dávalos and Ernesto Alfaro-Moreno

    Particle and Fibre Toxicology 2016 13:36

    Published on: 23 June 2016

  20. Research

    No involvement of alveolar macrophages in the initiation of carbon nanoparticle induced acute lung inflammation in mice

    Carbonaceous nanoparticles (CNP) represent a major constituent of urban particulate air pollution, and inhalation of high CNP levels has been described to trigger a pro-inflammatory response of the lung. While...

    Shanze Chen, Renfu Yin, Kathrin Mutze, Youjia Yu, Shinji Takenaka, Melanie Königshoff and Tobias Stoeger

    Particle and Fibre Toxicology 2016 13:33

    Published on: 21 June 2016

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