Particle and Fibre Toxicology

Table 6 Penetration of 10 μm (d _a ) through respiratory tract regions relative to particles entering the respiratory tract

From: Thoracic and respirable particle definitions for human health risk assessment

V _daily(%-tile)	Normal				Gradual
	Augmenter ^a		Mouth-breather ^a		Augmenter ^a		Oral only ^a
	P(ET) _avg	P(TB) _avg	P(ET) _avg	P(TB) _avg	P(ET) _avg	P(TB) _avg	P(ET) _avg	P(TB) _avg
Male
5%	0.05^b	0.03	0.21	0.10	0.11	0.05	0.43	0.21
50%	0.04	0.02	0.19	0.08	0.11	0.04	0.36	0.15
95%	0.03	0.01	0.19	0.06	0.10	0.03	0.32	0.12
Female
5%	0.06	0.03	0.15	0.07	0.06	0.03	0.41	0.20
50%	0.04	0.02	0.15	0.06	0.07	0.02	0.35	0.14
95%	0.03	0.01	0.16	0.05	0.07	0.02	0.31	0.11
Child-B ^c
5%	0.05	0.02	0.16	0.08	0.16	0.08	0.38	0.18
50%	0.03	0.01	0.15	0.06	0.14	0.06	0.31	0.13
95%	0.02	0.01	0.14	0.04	0.13	0.04	0.27	0.09
Child-A ^d
5%	0.10	0.05	0.21	0.10	0.21	0.10	0.38	0.18
50%	0.07	0.04	0.19	0.09	0.18	0.07	0.31	0.13
95%	0.05	0.02	0.17	0.05	0.16	0.05	0.27	0.09

P(ET), extrathoracic penetration for 10 μm particles; P(TB), tracheobronchial penetration for 10 μm particles; ^aData are daily averages, all activity levels weighted by daily ventilation; ^bFraction penetration; ^cScaling factor in Equations 2 and 3 equal to 1.26; ^dScaling factor in Equations 2 and 3 equal to 1.0.

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ISSN: 1743-8977

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