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Table 7 Inhalability adjusted particle penetration (50% cut-point) through respiratory tract regions

From: Thoracic and respirable particle definitions for human health risk assessment

V daily(%-tile)

Normal

 

Gradual

 
 

Augmenter

Mouth-breather

Augmenter

Oral only

 

P(ET) avg

P(TB) avg

P(ET) avg

P(TB) avg

P(ET) avg

P(TB) avg

P(ET) avg

P(TB) avg

Male

        

5%

2.92 a

2.72

4.97

4.24

3.55

3.22

8.24

6.38

95% CI

(1.71–4.90)

(1.64–4.26)

(3.09–7.66)

(2.81–5.85)

(2.11–5.82)

(2.00–4.85)

(5.66–11.4)

(4.89–7.59)

50%

2.44

2.30

4.93

4.21

3.33

3.02

7.52

5.90

95% CI

(1.43–4.12)

(1.37–3.67)

(3.11–7.51)

(2.84–5.67)

(1.99–5.43)

(1.87–4.54)

(5.12–10.5)

(4.50–6.98)

95%

2.14

2.02

4.92

4.22

3.15

2.88

7.14

5.71

95% CI

(1.25–3.62)

(1.20–3.29)

(3.13–7.44)

(2.87–5.64)

(1.89–5.15)

(1.78–4.36)

(4.84–10.1)

(4.32–6.77)

Female

        

5%

2.90

2.70

4.22

3.72

3.08

2.85

8.06

6.23

95% CI

(1.70–4.87)

(1.63–4.20)

(2.56–6.73)

(2.38–5.34)

(1.81–5.13)

(1.73–4.40)

(5.53–11.2)

(4.78–7.41)

50%

2.41

2.26

4.36

3.81

2.89

2.67

7.35

5.77

95% CI

(1.41–4.06)

(1.35–3.60)

(2.70–6.80)

(2.50–5.29)

(1.71–4.79)

(1.63–4.12)

(5.00–10.3)

(4.39–6.83)

95%

2.10

1.99

4.46

3.89

2.72

2.52

7.00

5.60

95% CI

(1.23–3.55)

(1.18–3.23)

(2.80–6.87)

(2.58–5.33)

(1.61–4.42)

(1.53–3.93)

(4.74–9.91)

(4.22–6.66)

Child-B b

        

5%

2.76

2.60

4.22

3.73

4.21

3.72

7.73

6.20

95% CI

(1.62–4.64)

(1.56–4.11)

(2.56–6.69)

(2.39–5.38)

(2.56–6.68)

(2.39–5.37)

(5.28–10.8)

(4.65–7.52)

50%

2.24

2.13

4.27

3.75

3.99

3.54

7.05

5.63

95% CI

(1.31–3.79)

(1.27–3.44)

(2.65–6.66)

(2.46–5.20)

(2.45–6.30)

(2.28–5.01)

(4.77–9.98)

(4.25–6.74)

95%

1.89

1.80

4.25

3.71

3.91

3.45

6.56

5.21

95% CI

(1.10–3.21)

(1.07–2.96)

(2.67–6.56)

(2.47–4.99)

(2.42–6.12)

(2.25–4.78)

(4.42–9.37)

(3.96–6.15)

Child-A c

        

5%

3.87

3.52

5.40

4.62

5.39

4.61

7.73

6.20

95% CI

(2.28–6.36)

(2.17–5.27)

(3.34–8.32)

(3.07–6.32)

(3.34–8.31)

(3.06–6.31)

(5.28–10.8)

(4.65–7.52)

50%

3.15

2.92

5.20

4.44

4.96

4.28

7.05

5.63

95% CI

(1.85–5.29)

(1.77–4.49)

(3.26–7.96)

(3.00–5.88)

(3.09–7.66)

(2.86–5.75)

(4.77–9.98)

(4.25–6.74)

95%

2.66

2.49

5.00

4.26

4.73

4.07

6.56

5.21

95% CI

(1.56–4.47)

(1.50–3.91)

(3.16–7.64)

(2.92–5.51)

(2.96–7.29)

(2.74–5.39)

(4.42–9.37)

(3.96–6.15)

  1. P(ET)avg, extrathoracic particle penetration which is the thoracic particle fraction averaged across all activity levels weighted by daily ventilation; P(TB)avg, tracheobronchial particle penetration which is the respirable particle fraction averaged across all activity levels weighted by daily ventilation; 95% CI, ninety-five percent confidence intervals for inter-individual variability attributable to differences in particle penetration through the extrathoracic region; a Aerodynamic particle diameter in μm; b Scaling factor in Equations 2 and 3 equal to 1.26; c Scaling factor in Equations 2 and 3 equal to 1.0.