Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Table 3 Uptake of AuNP in BAL macrophages at 0 h and 24 h after aerosol inhalation

Animals	N _O	N _P	N _E	RDI	Partial χ ²	Partial χ ²as%
Wt 0 h	95	35392	75.7	1.3*	4.9	37.6
Wt 24 h	52	33328	71.3	0.7	5.2	62.4
*Total*	147	68720			10.1
Tg 0 h	29	18688	42.2	0.7	4.1	48.5
Tg 24 h	83	30944	69.8	1.2*	2.5	51.7
*Total*	112	49632			6.6

N_O, number of observed particles; N_P, number of observed points (hitting a macrophage) per animal; N_E, number of expected particles; RDI, relative deposition index. *RDI > 1 and partial χ² > 30% indicate a preferentially populated compartment, i.e. more AuNP were found than expected for random AuNP distribution. Tg, Scnn1b-transgenic mice; Wt, wild-type mice.

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