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Table 3 Uptake of AuNP in BAL macrophages at 0 h and 24 h after aerosol inhalation

From: Cellular uptake and localization of inhaled gold nanoparticles in lungs of mice with chronic obstructive pulmonary disease

Animals N O N P N E RDI Partial χ 2 Partial χ 2as%
Wt 0 h 95 35392 75.7 1.3* 4.9 37.6
Wt 24 h 52 33328 71.3 0.7 5.2 62.4
Total 147 68720    10.1  
Tg 0 h 29 18688 42.2 0.7 4.1 48.5
Tg 24 h 83 30944 69.8 1.2* 2.5 51.7
Total 112 49632    6.6  
  1. NO, number of observed particles; NP, number of observed points (hitting a macrophage) per animal; NE, number of expected particles; RDI, relative deposition index. *RDI > 1 and partial χ2 > 30% indicate a preferentially populated compartment, i.e. more AuNP were found than expected for random AuNP distribution. Tg, Scnn1b-transgenic mice; Wt, wild-type mice.