Figure 2
From: Placental DNA hypomethylation in association with particulate air pollution in early life
Relative difference in global DNA methylation of placental tissue in association with in utero exposure to particulate air pollution (PM 2.5 ) during various time windows ( n = 240). The effect size is a relative difference (95% CI) in mean placental global DNA methylation for each 5 μg/m3 increase of PM2.5 exposure (μg/m3). Model 1 (●) is adjusted for newborn’s gender, maternal age, gestational age, parity, maternal education, smoking status, prenatal acetaminophen use, season at conception and trimester-specific apparent temperature. Model 2 (■) is additionally adjusted for the corresponding NO2 and maximum 8-hour average O3 exposure.