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Table 11 Dosimetry and calculated surface and volume lung burden

From: Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

  MWCNT Graphene Graphite nanoplatelets Carbon black
Highest target concentration [mg/m3] 2.5 10 10 10
Hg surface area [m2/g] 161 131 74 32
Apparent density [g/mL] 0.15 0.04 0.02 0.52
Calculated deposition using apparent density [mg/lung]* 0.03 0.26 0.20 0.10
Calculated volumetric lung burden using apparent density [μL/lung]** 0.19 4.79 3.67 0.50
Agglomerate density [g/mL] 0.39 0.29 0.89 1.05
Calculated deposition using agglomerate density [mg/lung]* 0.03 0.30 0.11 0.33
Calculated volumetric lung burden using agglomerate density [μL/lung]** 0.07 1.02 0.52 0.31
Calculated surface lung burden using agglomerate density [m2/lung] 0.005 0.039 0.008 0.010
Pulmonary response +++ + (−) -
  1. * Calculated with Multiple-Path Particle Dosimetry Model (MPPD v 2.11).
  2. ** Based on calculated disposition data.