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Table 6 Mediator levels in lung tissue after exposure to MWCNT

From: Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

  Study day 7 Study day 28
Concentration [mg/m3] 0.1 0.5 2.5 0.1 0.5 2.5
CINC-1/IL-8 1.2 3.0** 6.8** 1.0 1.9* 4.6**
KC/GROα 2.0 9.7** 21.3** 1.0 3.3* 18.8**
MCP-1 1.1 1.2 3.1** 0.8 0.9 1.8*
MCP-3 0.9 1.0 2.2** 0.9 1.0 1.7*
M-CSF 1.2 1.5* 2.3** 1.1 1.2* 1.6**
MDC 1.4 2.1 8.8** 0.9 1.0 2.6*
MIP-2 1.2 2.5** 5.1** 0.9 1.4* 4.2**
MPO 1.3 1.3 2.2** 1.1 1.0 1.3
NGAL 1.4* 2.2** 4.7** 1.1 1.2 2.9**
Osteopontin 1.1 1.6 3.1** 0.6 0.9 2.9**
  1. * Statistically significant, p < 0.05; ** statistically significant, p < 0.01.
  2. Differences are expressed as x-fold ratios compared to the concurrent control group.