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Table 6 Mediator levels in lung tissue after exposure to MWCNT

From: Comparative inhalation toxicity of multi-wall carbon nanotubes, graphene, graphite nanoplatelets and low surface carbon black

 

Study day 7

Study day 28

Concentration [mg/m3]

0.1

0.5

2.5

0.1

0.5

2.5

CINC-1/IL-8

1.2

3.0**

6.8**

1.0

1.9*

4.6**

KC/GROα

2.0

9.7**

21.3**

1.0

3.3*

18.8**

MCP-1

1.1

1.2

3.1**

0.8

0.9

1.8*

MCP-3

0.9

1.0

2.2**

0.9

1.0

1.7*

M-CSF

1.2

1.5*

2.3**

1.1

1.2*

1.6**

MDC

1.4

2.1

8.8**

0.9

1.0

2.6*

MIP-2

1.2

2.5**

5.1**

0.9

1.4*

4.2**

MPO

1.3

1.3

2.2**

1.1

1.0

1.3

NGAL

1.4*

2.2**

4.7**

1.1

1.2

2.9**

Osteopontin

1.1

1.6

3.1**

0.6

0.9

2.9**

  1. * Statistically significant, p < 0.05; ** statistically significant, p < 0.01.
  2. Differences are expressed as x-fold ratios compared to the concurrent control group.