Fold change RNA of NHBE cells grown in 95% air-5% CO
(normoxia) and 95% N
(hypoxia) for 24 hours and exposed to 250 μg NIST 1648 in 25 μL for 4 hr. The change in RNA for normoxic and hypoxic cells are provided relative to unexposed normoxic and hypoxic cells respectively. While IL-8 and HOX1 RNA was significantly elevated after particle exposure, fold change RNA after hypoxia was significantly increased relative to normoxia. *Significant difference relative to exposed normoxia.