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Table 1 Grafting amount and size of SNP after different steps of synthesis: plain SNP (SNP) to amine-modified SNP (aSNP), to alkyne-modified (aaSNP) and to final PEG-coated SNP

From: Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice

Sample

Weight Loss (%) a

Grafting amount (t, mmol/g) a

Grafting density (group/nm 2) a

Size (nm) b

plain SNP

1.7g

1.9h

8.1h

30c

aSNP

3.6

0.63

2.7

103d

aaSNP

2.4

0.29

1.2

126e

PEG-coated SNP

3.6

0.15

0.7

90c

  1. aWeight loss, grafting amount and density were calculated for each modification step, not for total modification. b Size were measured by dynamic light scattering as mono-distribution after sonication for 30-60 min. c Size was measured in H2O. d Size was measured in dimethylformamide triethylamine (DMF-TEA) (3:1). e Size was measured in DMF. g Weight loss of water from surface of bare silica particle. h Grafting amount and density of Si-OH available for modification on the surface calculated from water loss.