Table 2 Detailed gene expression analysis of responsive genes
From: Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice
Gene symbol | Gene alias | Gene function | Saline/0 μg NP | Saline/400 μg NP | OVA/0 μg NP | OVA/400 μg NP |
|---|---|---|---|---|---|---|
Cxcl1 | KC | Neutrophil chemokine | 1.00+/-0.05 | 2.80+/-0.78a | 2.48+/-0.28b | 6.29+/-0.38a,b |
Cxcl2 | MIP-2 | PMN chemokine | 1.00+/-0.08 | 2.85+/-0.75a | 4.22+/-0.76b | 8.77+/-0.99a,b |
Cxcl10 | IP10 | T-cell chemokine | 1.00+/-0.05 | 1.17+/-0.05 | 14.32+/-3.95b | 44.84+/-4.29a,b |
Ccl2 | MCP-1 | Monocyte and T-cell chemokine | 1.00+/-0.08 | 1.50+/-0.28 | 3.66+/-0.86b | 13.84+/-1.71a,b |
Ccl8 | MCP-2 | Monocyte chemokine | 1.00+/-0.08 | 1.56+/-0.25 | 15.48+/-5.22b | 105.12+/-32.47a,b |
Ccl11 | Eotaxin | Eosinophil chemokine | 1.00+/-0.05 | 1.32+/-0.11 | 2.50+/-0.71 | 11.47+/-2.84a,b |
Itln1 | Itlna | Pathogen-associated molecular pattern recognition | 1.00+/-0.25 | 4.95+/-1.78a | 6.14+/-0.95b | 38.65+/-13.92a,b |
Irg1 | Irg1 | Toll like receptor response | 1.00+/-0.14 | 4.70+/-1.15a | 15.45+/-4.36b | 154.18+/-16.97a,b |
Chi3l3 | YM1 | Chitinase-like protein | 1.00+/-0.07 | 1.01+/-0.12 | 1.30+/-0.26 | 1.94+/-0.28b |
Chi3l4 | YM2 | Chitinase-like protein | 1.00+/-0.35 | 4.61+/-2.98 | 9.13+/-3.96 | 33.10+/-12.56b |
Saa3 | Saa3 | Acute phase protein | 1.00+/-0.09 | 4.51+/-1.85 | 65.9+/-12.7b | 157.88+/-19.38a,b |
Tnfα | TNFα | Acute phase response cytokine | 1.00+/-0.12 | 1.69+/-0.17a | 2.20+/-0.23b | 3.36+/-0.30b |
Il6 | IL6 | Acute phase response cytokine | 1.00+/-0.13 | -1.14+/-0.13 | 2.00+/-0.40b | 5.60+/-0.96a,b |
Il1β | IL1β | Acute phase response cytokine | 1.00+/-0.13 | 1.01+/-0.05 | 1.26+/-0.03 | 1.71+/-0.13b |
Il1rn | IL1rn | IL1 receptor antagonist | 1.00+/-0.04 | 1.13+/-0.07 | 1.70+/-0.23 | 4.62+/-0.71a,b |
Il2 | IL2 | Th1 cytokine | 1.00+/-0.06 | 1.06+/-0.07 | 1.57+/-0.24b | 1.37+/-0.09 |
Ifnγ | IFNγ | Th1 cytokine | 1.00+/-0.08 | -1.06+/-0.14 | 1.67+/-0.28b | 2.31+/-0.30b |
Il4 | IL4 | Th2 cytokine | 1.00+/-0.15 | 1.01+/-0.12 | 1.40+/-0.26 | 3.77+/-0.77a,b |
Il5 | IL5 | Th2 cytokine | 1.00+/-0.10 | -1.20+/-0.18 | 2.39+/-0.59 | 7.17+/-1.44a,b |
Il13 | IL13 | Th2 cytokine | 1.00+/-0.10 | 1.34+/-0.39 | 6.80+/-2.96b | 44.23+/-12.67a,b |
Retnla | Fizz 1, HIMF | Th2 suppressor | 1.00+/-0.12 | 1.32+/-0.37 | 6.88+/-1.78b | 21.90+/-3.98a,b |
Il17a | IL17A | Th17 cytokine | 1.00+/-0.16 | 2.52+/-0.69 | 8.34+/-2.32b | 46.24+/-6.02a,b |
Foxp3 | Foxp3 | T-reg transcription factor | 1.00+/-0.08 | 1.49+/-0.18 | 2.08+/-0.19b | 3.98+/-0.33a,b |
Il10 | IL10 | T-reg cytokine | 1.00+/-0.09 | 1.09+/-0.17 | 2.97+/-0.76b | 8.22+/-2.01a,b |
Muc5ac | Muc5ac | Mucin production | 1.00+/-0.19 | 1.61+/-0.61 | 4.72+/-1.44b | 25.97+/-4.70a,b |
Clca3 | Gob5 | Ion channel, mucus secretion | 1.00+/-0.39 | 2.52+/-1.42 | 6.16+/-2.26 | 16.72+/-3.42b |
Clca2 | Clca2 | Ion channel, fibrosis development | 1.00+/-0.12 | 1.40+/-0.16 | 3.25+/-0.78b | 7.96+/-1.20a,b |
Mmp12 | Mmp12 | Macrophage elastase | 1.00+/-0.08 | 3.06+/-0.81 | 1.83+/-0.22 | 7.91+/-0.59 |
Timp1 | Timp1 | Mmp inhibitor | 1.00+/-0.05 | -1.00+/-0.10 | 3.73+/-0.87b | 12.40+/-1.68a,b |