Figure 1

DNA methylation differences in LINE-1 subfamilies between low and high exposure groups. Mean DNA methylation levels and 95% confidence intervals of L1PA5 (panel A), L1PA2 (panel B), L1Hs (panel C), and L1Ta (panel D) in low and high exposure groups are shown for each of the studies. Open circles represent low exposure group (Steelworkers in low exposure job position in Study 1; indoor office workers in Study 2 and Study 3); closed circles represent high exposure group (Steel workers in high exposure job position in Study 1; gas station attendants in Study 2; and truck drivers in Study 3). Significant p-values (< 0.05) for DNA methylation differences between low and high exposure groups are shown in the figures.