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Table 3 Dose–response relationship between levels of personal air pollutants exposure and DNA methylation in the participants

From: Evolutionary age of repetitive element subfamilies and sensitivity of DNA methylation to airborne pollutants

Repetitive element Study 1 associations with metal-rich particulate matter (PM 10) Study 2 associations with air benzene Study 3 associations with traffic-derived elemental carbon
Family Subfamily τ a p value τ a p value τ a p value
  L1PA5 -15.2 0.02* -2.3 0.28 5.6 0.01*
LINE-1 L1PA2 -5.8 0.03* -4.3 0.01* -2.3 0.51
  L1Hs 1.4 0.68 1.0 0.60 -2.7 0.19
  L1Ta -4.2 0.17 0.7 0.74 1.6 0.68
  Alu Sx 0.0 1.00 1.0 0.21 0.0 1.00
Alu Alu Yb8 -3.8 0.11 -0.4 0.74 2.4 0.14
  Alu Yd6 -6.6 0.31 -4.1 0.37 4.0 0.29
  MLT1D -47.6 0.16 54.6 0.13 -41.8 0.09
HERV ERV1 0.4 0.78 0.6 0.56 0.0 0.99
  ERV9 1.9 0.45 1.4 0.42 0.5 0.83
  1. a τ = (2β - 1) * 100 represents the percent-change of the ratio methylated/unmethylated associated with an increase in the exposure from the 25th to the 75th percentile, adjusted for age and smoking.
  2. * p< 0.05.