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Table 1 Selection of NLRP3 inflammasome and IL-1 family member related genes

From: Silica induces NLRP3 inflammasome activation in human lung epithelial cells

BEAS-2B

 

mRNA

Gene symbol

Gene name

Fold Change ↑

IL1A

Interleukin 1, alpha

6,2*

IL1RL1

Interleukin 1 receptor-like 1

5,4

IL1B

Interleukin 1, beta

3,6*

NLRP1

NLR family, pyrin domain containing 1

3,4

NLRP3

NLR family, pyrin domain containing 3

2,5*

IL1RL2

Interleukin 1 receptor-like 2

2,3

IL18R1

Interleukin 18 receptor 1

2,2

IL1RAP

Interleukin 1 receptor accessory protein

2,2

NHBE

  
 

Gene name

Fold Change ↑

IL1F9

Interleukin 1 family, member 9

14,0

TXNIP

Thioredoxin interacting protein

9,7

IL1F5

Interleukin 1 family, member 5 (delta)

6,0

IL32

Interleukin 32

5,5

IL1RL1

Interleukin 1 receptor-like 1

3,5

CASP1

Caspase 1 (interleukin-1 beta convertase)

2,1*

bFGF

Fibroblast growth factor 2 (basic)

2,1

IL1A

Interleukin 1, alpha

2,1

  1. For each cell type a selection of genes was collected from previously described microarray data set [18]. All transcripts are involved in inflammasome and IL-1 immune- cytokine responses.
  2. * = confirmed by qRT-PCR.