Table 2 Mean residence time (MRT) of silver after 28 days of oral administration
From: Biopersistence of silver nanoparticles in tissues from Sprague–Dawley rats
Tissue | Male | Female | ||
|---|---|---|---|---|
100 mg/kg/day | 500 mg/kg/day | 100 mg/kg/day | 500 mg/kg/day | |
(days) | (days) | (days) | (days) | |
A. 10 nm | ||||
Blood | 2.85 | 10.02 | 4.70 | 11.24 |
Brain | 58.60 | 54.44 | 57.82 | 53.54 |
Kidneys | 31.03 | 49.12 | 42.10 | 49.60 |
Liver | 21.49 | 32.05 | 48.77 | 29.82 |
Spleen | 38.24 | 43.43 | 39.52 | 43.58 |
Testes/Ovaries | 55.32 | 63.68 | 44.70 | 44.19 |
B. 25 nm | ||||
Blood | 3.75 | 6.47 | 5.53 | 11.25 |
Brain | 55.06 | 52.43 | 58.57 | 56.93 |
Kidneys | 25.80 | 34.67 | 34.33 | 46.72 |
Liver | 22.40 | 29.99 | 33.89 | 37.42 |
Spleen | 30.75 | 40.95 | 48.11 | 35.81 |
Testes/Ovaries | 55.34 | 63.31 | 48.29 | 41.75 |