Extrapulmonary transport of MWCNT following inhalation exposure

Table 1 Extrapulmonary MWCNT concentration, number

Day post-inhalation ¹	Organ	Weight gm	Concentration #/gm tissue	Total #	% of lung burden ²
1	Lymph Nodes	0.03	508,776,984	14,263,560	1.08000
	Liver	1.53	25,767	39,303	0.00281
	Kidney	0.45	16,639	7,438	0.00105
	Heart	0.12	11.849	1,371	0.00022
	Brain	0.38	7,231	2,776	0.00101
	Chest Wall	1.00	13,774	13,764	0.00354
	Diaphragm	0.07	6,767	507	0.00025
				Total%	1.089%
336	Lymph Nodes	0.05	1,807,273,684	84,845,500	7.30000
	Liver	1.83	196,798	360,456	0.02740
	Kidney	0.54	126,973	68,165	0.00520
	Heart	0.14	62,401	8,670	0.00070
	Brain	0.46	53,569	24,740	0.00190
	Chest Wall	1.07	10,382	12,457	0.00090
	Diaphragm	0.09	59,915	5,392	0.00040
				Total%	7.337%

¹Body weights of MWCNT exposed mice were 22.9 ± 0.5 and 40.5 ± 2.2 g at 1 day and 336 days post-exposure, respectively.
²100 × Total number of fibers in organ divided by 1 day post-exposure lung burden of 1,321 million fibers per lung.

ISSN: 1743-8977