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Table 4 Oxidative stress in mouse kidney after intragastric administration of TiO 2 NPs for 90 consecutive days

From: RETRACTED ARTICLE: Intragastric exposure to titanium dioxide nanoparticles induced nephrotoxicity in mice, assessed by physiological and gene expression modifications

Oxidative stress

TiO2NPs (mg/kg BW)

 

0

2.5

5

10

O2 .- (nmol/mg prot. min)

18 ± 0.9a

25 ± 1.23b

38 ± 1.91c

43 ± 2.15d

H2O2 (nmol/mg prot. min)

31 ± 1.55a

46 ± 2.28b

77 ± 3.845c

92 ± 4.6d

MDA (μmol/ mg prot)

1.02 ± 0.05a

1.97 ± 0.10b

3.05 ± 0.15c

4.88 ± 0.24d

Carbonyl (μmol/mg prot)

0.51 ± 0.03a

1.13 ± 0.06b

1.89 ± 0.09c

2.79 ± 0.14d

8-OHdG (mg/g tissue)

0.48 ± 0.02a

2.16 ± 0.11b

3.58 ± 0.18c

5.87 ± 0.29d

  1. Different letters indicate significant differences between groups (p < 0.05). Values represent means ± SEM (N = 5).