Bioenergetic failure correlates with autophagy and apoptosis in rat liver following silver nanoparticle intraperitoneal administration

Table 1 Time course of changes in serum enzyme activities in rats following intraperitoneal administration of Ag-nps

Time after treatment (day)	Group	AST (U/L)	ALT (U/L)
1	Sham	84.00 ± 27.46 **	45.93 ± 12.70**
1	Ag-nps	128.13 ± 40.99	25.68 ± 10.72
4	Sham	84.00 ± 27.55 *	49.13 ± 11.80**
4	Ag-nps	99.24 ± 20.90	36.09 ± 13.21
7	Sham	87.17 ± 16.82 **	51.31 ± 11.63
7	Ag-nps	131.13 ± 37.40	50.71 ± 10.03
10	Sham	86.75 ± 10.01**	50.00 ± 11.07
10	Ag-nps	157.15 ± 47.03	50.15 ± 13.28
30	Sham	94.67 ± 13.58*	48.50 ± 6.81*
	Ag-nps	139.25 ± 11.69	58.44 ± 12.18

Values were mean ± standard deviations of the mean. N = 8 at each time point for each group. Ag-nps were administered, i.p., at 500 mg kg^-1 body weight. AST = aspartate aminotransferase; ALT = alanine aminotrasferase. *p < 0.05, **p < 0.01 as compared to sham groups.

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