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Table 1 Histopathological grades of nasal cavity, brain, and liver tissue samples collected from three different BALB/c mice exposed to nSP30, nSP70, mSP300, nSP100, or mSP1000 via intranasal administration

From: Intranasal exposure to amorphous nanosilica particles could activate intrinsic coagulation cascade and platelets in mice

Findings

Control

mSP1000

mSP300

nSP100

nSP70

nSP30

Nasal cavity

      

Cell aggregation

0 0 0

0 0 0

0 0 0

0 0 0

0 0 0

1 1 1

Brain

      

Microglial aggregation

1 1 0

1 1 0

1 2 1

1 0 0

2 1 0

1 1 1

Liver

      

Cell aggregation

1 2 0

1 2 1

1 1 0

1 1 1

0 0 0

0 1 1

Rarefaction

3 3 2

3 3 2

3 3 3

3 3 3

3 2 2

3 3 2

  1. Grade; 0: none, 1: very slight, 2: mild, 3: moderate, 4: advanced.