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Table 3 BALF cytology and estimation of NP endocytosis by macrophages following inhalation exposure

From: Rat pulmonary responses to inhaled nano-TiO2: effect of primary particle size and agglomeration state

Experimental groups

Cell type

Control

5 nm SA

5 nm LA

10-30 nm SA

10-30 nm LA

50 nm SA

50 nm LA

Total cells a

2.36±0.46

4.32±0.27*

4.02±0.63

4.41±0.40*

5.38±0.45**

3.01±0.36

4.82±0.36**

Lymphocytes b

4.16±0.60

2.15±0.37

8.08±1.97

4.57±0.82

7.02±2.67

2.85±0.49

4.34±1.37

Neutrophils c

0.23±0.05

1.18±0.19

1.18±0.34

1.26±0.16

1.47±0.41*

0.84±0.18

1.78±0.22**

Macrophages a

2.30±0.45

4.18±0.27*

3.82±0.59

4.24±0.39*

5.16±0.42**

2.90±0.35

4.60±0.36**

Estimation of endocytosis (%) d

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53±3.8ŧ

78±1.3

53±1.9ŧ

78±2.9

65±1.9ŧ

83±1.3

  1. a number of cells x 106 ± standard error on the mean (SEM); b number of cells x 104 ± SEM; c number of cells x 105 ± SEM; d estimation of the extend of NP phagocytosis by macrophages. Mean values (n = 6 rats per group) significantly different from controls (ANOVA followed by a Tukey’s test) *p<0.05, **p<0.01, ŧp<0.05 significantly different from LA aerosol of the same primary NP size.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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