Figure 2
Lung injury in vivo. Indices of lung injury measured in the acellular BALF recovered from rats 1, 3, 5, 7, 14, and 28 days after intratracheal-instillation with 1.25, 5.0, or 12.5 μg of QD-NH2 or QD-COOH: (A) Lactate dehydrogenase (LDH), an indicator of general cytotoxicity, and (B) albumin, an indicator of damage to the air-blood barrier. * significantly different from all groups; + significantly different from saline, 1.25 μg, and 5.0 μg groups; # significantly different from saline and 1.25 μg groups; @ significantly different from saline, 1.25 μg groups, and QD-NH2 at 5.0 μg; X significantly different from saline, 1.25 μg groups, and QD-COOH at 5.0 μg; ^ significantly different from saline (p<0.05).