Figure 5
Histopathological evaluation of pulmonary injury and inflammation. Micrographs of H&E-stained tissue sections from rats 28 days after intratracheal instillation with saline (A), QD-NH2 (B), or QD-COOH (C &D). At 28 days after instillation of QD-NH2, infiltration of leukocytes around a blood vessel and in alveoli are present, with minimal thickening of alveoli septa (B, black arrows). At 28 days in the QD-COOH group, alveolar walls are thickened (C, black arrows) and alveoli contain foamy macrophages, and hyperplastic Type II epithelial cells can be found in alveoli (D, yellow arrows). V, vessel.