Figure 7
Confocal evaluation of AM uptake of QD in vivo. Confocal micrographs (63x-zoomed or 100x objective) of AM from the BAL of rats 1 (A-C) and 28 (D-F) days after intratracheal instillation with 12.5 μg QD-NH2 or QD-COOH (red/yellow), or PBS (control): (A) control – 1 day post-exposure, (B) QD-NH2 - 1 day post-exposure, (C) QD-COOH – 1 day post-exposure, (D) control – 28 days post-exposure, (E) QD-NH2 - 28 days post-exposure, and (F) QD-COOH – 28 days post-exposure. AM are green and QD are yellow/red. PMN uptake of QD is shown in the smaller inset micrograph in panel C (arrows).