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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Towards predicting the lung fibrogenic activity of nanomaterials: experimental validation of an in vitro fibroblast proliferation assay

Figure 4

In vitro effect of MWCNT on proliferation of several fibroblast types assessed by cell counting. Primary murine lung fibroblasts and human and mouse fibroblast cell lines (HFL-1, BALB/3T3 and MLg) were treated for 24 h with different doses of NM400 dispersed in 1.4 mg BSA /ml (final concentration 0.14 mg BSA /ml). PDGF-BB (50 ng/ml) was used as a positive control. Results are expressed relative to non-treated cell number (Ctl). * p < 0.05, ** p < 0.01, *** p < 0.001 vs non-treated cells (n = 3, t-test or Dunnet multiple comparison test as appropriate).

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