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Table 2 Canonical pathways most significantly perturbed at the transcriptional level in hONS cells exposed to ZnO nanoparticles

From: Surface coatings of ZnO nanoparticles mitigate differentially a host of transcriptional, protein and signalling responses in primary human olfactory cells

Particle

Top 5 Canonical pathways perturbed at 2 h

p - value

Top 5 Canonical pathways perturbed at 6 h

p value 2

Z-COTE uncoated

Aldosterone signalling in epithelial cells

1.97E - 10

Nucleotide excision repair pathway

1.30E - 05

NRF2-mediated oxidative stress response

1.33E - 08

Endoplasmic reticulum stress pathway

2.75E - 04

Protein ubiquitination pathway

3.66E - 06

Protein ubiquitination pathway

6.82E - 04

Glucocorticoid receptor signalling

3.53E - 05

Ubiquinone bisoynthesis

9.82E - 04

Huntingtons’s disease signalling

7.91E - 05

Assembly of RNA Polymerase II complex

1.24E - 03

Nanosun uncoated

Aldosterone signalling in epithelial cells

4.70E - 07

Ubiquinone biosynthesis

9.92E - 12

NRF2-mediated oxidative stress response

1.31E - 05

Mitochondrial dysfunction

4.00E - 11

IL-17A signalling in fibroblasts

6.40E - 05

Nucleotide excision repair pathway

5.92E - 11

Production of nitric oxide and reactive oxygen species in macrophages

1.17E - 04

Oxidative phosphorylation

2.70E - 09

Glucocorticoid receptor signalling

1.87E - 04

Protein ubiquitination pathway

1.60E - 08

HP1 coated (Triethoxycaprylysilane)

Aldosterone signalling in epithelial cells

4.12E - 07

Glucocorticoid receptor signalling

1.25E - 07

NRF2-mediated oxidative stress response

1.17E - 06

Aldosterone signalling in epithelial cells

5.85E - 06

Glucocorticoid receptor signalling

1.50E - 04

Protein ubiquitination pathway

8.79E - 06

IL - 17A signalling in fibroblasts

4.88E - 04

NRF2-mediated oxidative stress response

7.27E - 05

Protein ubiquitination pathway

9.24E - 04

Assembly of RNA Polymerase II complex

9.05E - 05

MAX coated (Dimethoxydiphenylsilane/triethoxycaprylylsilane cross-polymer)

Aldosterone signalling in epithelial cells

7.40E - 04

Hereditary breast cancer signalling

6.11E - 06

NRF2-mediated oxidative stress response

1.01E - 03

Aminoacyl-tRNA biosynthesis

4.24E - 05

IL-10 signalling

2.71E - 03

Glucocorticoid receptor signalling

5.61E - 05

Protein ubiquitination pathway

2.85E - 03

Mismatch repair in eukaryotes

7.59E - 05

Endothelin-1 signalling

1.48E - 02

Nucleotide excision repair pathway

1.04E - 04