Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

Table 1 Physicochemical properties of the panel of nanoparticles

NP ^a	Primary size (nm) ^b	Surface area (m ²/g) ^c	Hydrodynamic size (nm) in 5% FBS	Mass (μg) for 30 cm ²
CeO₂	9.7 ± 0.4	24.1	69.3 ± 8.0	125
TiO₂-rutile	30.5 ± 1.8	27.5	89.9 ± 13.1	109
CB	15.3 ± 6.0	254	45.1 ± 9.8	11.8
SiO₂	6.2 ± 0.4	523.4	398.1 ± 24.8	5.0
NiO	5.3 ± 0.4	91.8	100.8 ± 38.5	32.7
Co₃O₄	18.4 ± 0.8	35.8	148.2 ± 95.5	83.8
Cr₂O₃	205 ± 20.7	74.42	195.3 ± 101.4	40.3
ZnO	10.7 ± 0.7	48.2	492.8 ± 25.2	62.0
CuO	23.1 ± 1.0	29	95.6 ± 1.6	103

^aNPs were provided by Nanostructural and Amorphous Materials Inc. (Houston, TX, USA) except for CB (Evonik Degussa GmbH, Frankfurt, Germany), ZnO (NanoScale Corporation, Manhattan, KS, USA), and CuO (Sigma-Aldrich).
^bPrimary particle sizes were measured by a transmission electron microscopy.
^cSurface area was measured by BET (Brunauer-Emmett-Teller) method.

ISSN: 1743-8977