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Table 2 The number of total granulocytes in the BAL at 24 h after instillation of NPs into rats

From: Predictive value of in vitro assays depends on the mechanism of toxicity of metal oxide nanoparticles

NP

Total cells (×10 5)

Granulocytes (×10 5)

Vehicle control

7.5 ± 3.1

0.2 ± 0.1

CeO2

42.3 ± 25.9**

37.1 ± 23.2***

TiO2-rutile

7.6 ± 2.6

1.5 ± 1.8

CB

13.1 ± 4.4

8.0 ± 3.3

SiO2

6.1 ± 1.0

0.5 ± 0.7

NiO

45.5 ± 16.8**

35.0 ± 17.0***

Co3O4

104.4 ± 12.4***

93.8 ± 11.3***

Cr2O3

39.9 ± 12.1**

1.7 ± 1.6

ZnO

16.0 ± 4.1

13.2 ± 5.0*

CuO

40.5 ± 3.6**

36.9 ± 3.8***

  1. The acute lung inflammogenicity data were used from our previously published data [16, 17].
  2. Significance versus vehicle control: * p < 0.05, ** p < 0.01, *** p < 0.001.