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Table 2 Bovine and human proteins immobilized onto nanoparticles surface analyzed with MALDI-TOF

From: Altered characteristics of silica nanoparticles in bovine and human serum: the importance of nanomaterial characterization prior to its toxicological evaluation

 

SiO2

SiO2_NH2

SiO2_SH

SiO2_PVP

1

2

3

4

5

1

2

3

4

5

1

2

3

4

5

1

2

3

4

5

FBS

Chain A, bovine serum albumin

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

Serum albumin precursor

x

x

x

  

x

x

x

    

x

 

x

     

Apolipoprotein A-I

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

Apolipoprotein E

 

x

x

x

x

  

x

x

x

  

x

       

Alpha-2-macroglobulin precursor

   

x

x

       

x

x

x

     

Plasminogen precursor

x

x

x

x

x

x

x

x

x

   

x

       

Gelsolin isoform b

x

x

x

x

x

x

x

x

x

 

x

 

x

 

x

     

Kelch-like protein 9

x

x

x

x

x

x

x

x

x

x

    

x

     

complement C4-A [a]

x

x

x

  

x

x

x

  

x

x

x

       

Human serum

                    

Chain A, human serum albumin

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

Chain A, lipid-free human apolipoprotein A-I

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  

x

x

x

Apolipoprotein A-IV precursor

x

x

   

x

    

x

         

Apolipoprotein B-100 precursor

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

Apolipoprotein E

 

x

          

x

x

x

     

Complement C4-A preproprotein

     

x

x

x

x

x

 

x

x

x

x

     

Complement C4-B-like preproprotein

     

x

x

             

Chain C, human complement component C3c

  

x

x

x

x

x

x

x

x

  

x

x

x

  

x

x

x

Alpha-1-antitrypsin

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

  

x

x

x

Chain A [b]

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

x

Coagulation factor II (thrombin)

  

x

x

x

x

x

x

x

x

  

x

x

x

  

x

x

x

Antithrombin III

     

x

x

             

Inter-alpha (globulin) inhibitor H2i

     

x

x

             
  1. (1) 5 min, (2) 1 h, (3) 24 h, (4) 72 h, (5) 1 week of NPs incubation in DMEM supplemented with 10% serum.
  2. [a] predicted; [b] an autoimmune complex between a human IgM rheumatoid factor and IgG1 factor reveals a novel factor epitope and evidence for affinity maturation.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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