Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study

Table 6 Effects of FA exposure and DE exposure on cell count in peripheral blood

Cell type	Cell count (×10 ⁹/L)					P-values for DE exposure vs. FA exposure
	Before exposure	After exposure	20 h post-exposure	Δ after exposure ^a	Δ 20 h post-exposure ^a	Δ after exposure ^a	Δ 20 h post-exposure ^a
*FA exposure*
Leukocytes	5.45±1.36	5.72±1.34	5.17±1.17	0.27±0.53	-0.28±1.02	--	--
Neutrophils	3.02±1.15	2.99±1.03	2.64±0.75	-0.04±0.31	-0.38±0.99	--	--
Eosinophils	0.19±0.09	0.20±0.11	0.21±0.11	0.01±0.06	0.02±0.06	--	--
Lymphocytes	1.69±0.49	2.02±0.64	1.83±0.53	0.33±0.32	0.14±0.30	--	--
Monocytes	0.49±0.13	0.48±0.15	0.44±0.12	-0.01±0.13	-0.05±0.11	--	--
*DE exposure*
Leukocytes	5.29±1.00	5.60±0.98	5.45±1.37	0.31±0.55	0.16±1.01	0.725	0.007
Neutrophils	3.00±0.81	2.91±0.63	2.89±1.04	-0.09±44	-0.11±0.93	0.474	0.139
Eosinophils	0.19±0.12	0.20±0.13	0.22±0.13	0.01±0.06	0.03±0.07	0.847	0.431
Lymphocytes	1.59±0.48	1.94±0.59	1.82±0.64	0.35±0.24	0.23±0.35	0.651	0.264
Monocytes	0.47±0.11	0.51±0.10	0.48±0.13	0.04±0.11	0.01±0.10	0.042	0.017

Values are mean ± standard deviation (SD).
DE, diesel exhaust; FA, filtered air.
^aΔ after exposure = after exposure – before exposure; Δ 20 h post-exposure = 20 h post-exposure – before exposure.

ISSN: 1743-8977