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Table 7 Effects of FA exposure and DE exposure on inflammatory markers

From: Effects of diesel exposure on lung function and inflammation biomarkers from airway and peripheral blood of healthy volunteers in a chamber study

Inflammatory markers

Concentration of markers

P-values for DE exposure vs. FA exposure

 

Before exposure

After exposure

20 h post-exposure

Δ after exposure a

Δ 20 h post-exposure a

Δ after exposure a

Δ 20 h post-exposure a

FA exposure

       

Serum IL-6 (pg/ml)

1.73±0.98

1.69±1.13

1.60±1.33

-0.04±0.56

-0.13±0.90

--

--

Serum IL-8 (pg/ml)

5.00±3.28

4.91±3.26

5.46±4.35

-0.09±1.33

0.46±2.48

--

--

NL IL-6 (pg/ml)

0.97±1.01

0.94±0.86

0.85±0.68

-0.03±0.93

-0.11±0.81

--

--

NL IL-8 (pg/ml)

67.0±73.3

48.5±50.5

49.9±66.6

-18.6±71.5

-17.1±49.4

--

--

NL TNF-α(pg/ml)

0.95±0.77

0.84±0.14

1.03±0.88

-0.10±0.79

0.08±1.19

--

--

NL ICAM-1(pg/ml)

76.8±87.1

76.6±101

62.0±73.9

-0.15±114

-14.7±64.0

--

--

CRP (mg/l)

1.6±1.6

1.5±1.7

1.3±1.2

-0.03±0.23

-0.27±0.54

--

--

Fibrinogen (g/l)

2.9±0.5

2.9±0.5

3.1±0.6

0.12±0.72

0.24±0.66

--

--

CC16 (μg/l)

5.93±1.98

5.84±2.20

6.73±2.38

-0.08±0.99

0.61±1.56

--

--

SP-D (μg/l)

66.9±34.0

66.7±35.0

70.8±36.1

-0.21±9.42

3.90±9.81

--

--

DE exposure

       

Serum IL-6 (pg/ml)

1.80±1.35

1.64±1.14

1.92±1.56

-0.16±0.64

0.12±0.78

0.413

0.066

Serum IL-8 (pg/ml)

5.10±3.62

4.85±3.79

5.59±3.74

-0.25±1.90

0.49±1.82

0.666

0.940

NL IL-6 (pg/ml)

1.32±2.03

1.29±2.08

2.01±5.04

-0.03±2.35

0.70±4.64

0.983

0.247

NL IL-8 (pg/ml)

71.3±71.7

63.9±97.8

48.6±46.7

-7.40±98.4

-22.7±48.1

0.483

0.597

NL TNF-α (pg/ml)

0.82±0.00

0.90±0.37

0.98±0.79

0.08±0.37

0.16±0.79

0.312

0.715

NL ICAM-1(pg/ml)

109.7±138

93.5±142

85.3±103

-16.2±114

-24.4±74.5

0.409

0.398

CRP (mg/L)

2.0±2.2

1.9±2.0

1.6±1.6

-0.12±0.24

-0.39±0.71

0.034

0.283

Fibrinogen (g/l)

3.2±0.7

3.3±0.8

3.4±01.0

0.13±0.55

0.26±0.84

0.968

0.940

CC16 (μg/l)

6.21±2.23

6.64±3.44

6.12±2.32

0.43±2.50

-0.09±1.44

0.224

0.016

SP-D (μg/l)

63.4±34.0

61.9±32.7

66.7±32.8

-1.45±4.78

3.34±12.1

0.626

0.838

  1. Values are mean ± standard deviation (SD).
  2. DE, diesel exhaust; FA, filtered air; NL, nasal lavage.
  3. aΔ after exposure = after exposure – before exposure; Δ 20 h post-exposure = 20 h post-exposure – before exposure.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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