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Figure 6 | Particle and Fibre Toxicology

Figure 6

From: Diesel exhaust particulate increases the size and complexity of lesions in atherosclerotic mice

Figure 6

Instillation of DEP increased expression of antioxidant genes in the liver, particularly in ApoE−/− mice. (a) NF-E2-related factor-2 (Nrf2), (b) NAD(P)H-quinone oxidoreductase-1 (NQO1) and (c) hemeoxygenase-1 (HO-1). Effect of DEP shown as fold-increase in the expression in saline-treated mice. Mean ± S.E.M. (n = 5-8), n.s. P > 0.05, *P < 0.05, ***P < 0.001, unpaired t-test comparing saline vs DEP. ApoE−/− were fed Western diet for 8 weeks, whereas wild-type mice were fed normal chow.

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