Instillation of DEP increased expression of antioxidant genes in the liver, particularly in ApoE−/−
mice. (a) NF-E2-related factor-2 (Nrf2), (b) NAD(P)H-quinone oxidoreductase-1 (NQO1) and (c) hemeoxygenase-1 (HO-1). Effect of DEP shown as fold-increase in the expression in saline-treated mice. Mean ± S.E.M. (n = 5-8), n.s.
P > 0.05, *P < 0.05, ***P < 0.001, unpaired t-test comparing saline vs DEP. ApoE−/− were fed Western diet for 8 weeks, whereas wild-type mice were fed normal chow.