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Figure 2 | Particle and Fibre Toxicology

Figure 2

From: Pulmonary diesel particulate increases susceptibility to myocardial ischemia/reperfusion injury via activation of sensory TRPV1 and β1 adrenoreceptors

Figure 2

Infarct size and oxidant stress generation was increased in hearts isolated from DEP instilled rats and perfused ex vivo . Myocardial infarct size (a, expressed as percentage of area at risk; AAR) and (b, c) oxygen free radicals (via quantification of CP˙ spin adducts by electron paramagnetic resonance; EPR) in coronary perfusate of hearts from non-instilled rats (non-instilled, grey column) and hearts isolated 6 h after instillation of saline (saline, 0.5 ml, open columns) or DEP (0.5 mg, black column). Results are expressed as mean ± SEM (n = 4-6) **P < 0.01, ***P < 0.001 saline versus DEP; one-way ANOVA followed by Bonferroni post-hoc test.

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