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Table 3 Intracellular cobalt solubilization assessed by single-cell quantitative imaging of cobalt (micro-PIXE) after exposure of BEAS-2B cells to Co 3 O 4 particles for 72 h

From: Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells

Co mean ± SD (fg/cell) IC25 IC50
Particulate Co 9500 ± 1650 20,450 ± 23,500
min 6593 – max 11,483 min 3062 – max 78,486
Solubilized Co 6.7 ± 3.0 48 ± 20
min 3.4 – max 11.5 min 12.0 - max 70.0
% solubilization 0.07 ± 0.03 0.55 ± 0.50
min 0.04% - max 0.12% min 0.06% - max 1.6%
  1. Mean ± SD for the particulate and solubilized intracellular fractions (n = 6 for IC25 and n = 9 for IC50). The solubilization percentage (mean ± SD) was also calculated from each single-cell analysis, and not from the mean solubilized to particulate ratios. Minimal and maximal values are indicated below the mean values.