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Table 3 Intracellular cobalt solubilization assessed by single-cell quantitative imaging of cobalt (micro-PIXE) after exposure of BEAS-2B cells to Co 3 O 4 particles for 72 h

From: Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells

Co mean ± SD (fg/cell)

IC25

IC50

Particulate Co

9500 ± 1650

20,450 ± 23,500

min 6593 – max 11,483

min 3062 – max 78,486

Solubilized Co

6.7 ± 3.0

48 ± 20

min 3.4 – max 11.5

min 12.0 - max 70.0

% solubilization

0.07 ± 0.03

0.55 ± 0.50

min 0.04% - max 0.12%

min 0.06% - max 1.6%

  1. Mean ± SD for the particulate and solubilized intracellular fractions (n = 6 for IC25 and n = 9 for IC50). The solubilization percentage (mean ± SD) was also calculated from each single-cell analysis, and not from the mean solubilized to particulate ratios. Minimal and maximal values are indicated below the mean values.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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