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Table 4 Summary of the results obtained for the intracellular quantification and distribution of solubilized cobalt after exposure of BEAS-2B cells for 72 h to Co 3 O 4 particles and soluble CoCl 2 (both at IC25)

From: Low-solubility particles and a Trojan-horse type mechanism of toxicity: the case of cobalt oxide on human lung cells

Analytical technique

Exposure compound

Intracellular solubilized Co

Mean ± SD (fg/cell)

PIXE

Co3O4

6.7 ± 3.0

nucleus : 3.3 ± 2.0

cytoplasm: 3.4 ± 1.5

ICP-MS

Co3O4

6.5 ± 2.0

PIXE

CoCl2

5.4 ± 0.8