Figure 9

Results of pulmonary mechanics measurements of mice after sub-acute (A) or sub-chronic (B) exposure to ZnO NPs or filtered laboratory air (sham). Resistance and compliance were measured after inhalation challenge to increasing concentration of methacholine (1, 3, 10, and 30 mg/mL). Plot B also shows resistance and compliance in positive control mice exposed by nasal instillation to bleomycin (fibrosis model) or house dust mite allergen (Dermatophagoides pteronyssinus, asthma model). No changes in pulmonary mechanics were observed in mice exposed to ZnO NPs for 2 (A) or 13 wks (B).