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Table 1 Summary of physicochemical properties of ZnO NPs and generated aerosol

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

  ZnO NPs
Primary particle size1 15 ± 4 nm (26 ± 11 nm)#
Crystalline or amorphous Crystalline, zincite
Surface functionality CO32−, OH, CH
BET surface area2 47 ± 1 m2/g (15 ± 4 m2/g)#
Nanoparticle dissolution Gamble’s solution (pH 7.4): < 1%
ALF* (pH 4.5): 100%
Aerosol characterization in the whole-body exposure chamber:
  Sub-acute study Sub-chronic study
Aerosol size distribution3 GM = 46 nm GM = 36 nm
GSD = 1.8 GSD = 1.8
Exposure mass concentration2 3.6 ± 0.5 mg/m3 3.3 ± 0.6 mg/m3
  1. 1Primary diameter as measured by TEM in our laboratory ± standard deviation (SD), 2Mean ± standard deviation, 3GM: Geometric mean mobility diameter and GSD: geometric standard deviation, #Analysis of ZnO NPs used in sub-chronic study in parenthesis. *ALF: artificial lysosomal fluid.