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Table 1 Summary of physicochemical properties of ZnO NPs and generated aerosol

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

 

ZnO NPs

Primary particle size1

15 ± 4 nm (26 ± 11 nm)#

Crystalline or amorphous

Crystalline, zincite

Surface functionality

CO32−, OH, CH

BET surface area2

47 ± 1 m2/g (15 ± 4 m2/g)#

Nanoparticle dissolution

Gamble’s solution (pH 7.4): < 1%

ALF* (pH 4.5): 100%

Aerosol characterization in the whole-body exposure chamber:

 

Sub-acute study

Sub-chronic study

Aerosol size distribution3

GM = 46 nm

GM = 36 nm

GSD = 1.8

GSD = 1.8

Exposure mass concentration2

3.6 ± 0.5 mg/m3

3.3 ± 0.6 mg/m3

  1. 1Primary diameter as measured by TEM in our laboratory ± standard deviation (SD), 2Mean ± standard deviation, 3GM: Geometric mean mobility diameter and GSD: geometric standard deviation, #Analysis of ZnO NPs used in sub-chronic study in parenthesis. *ALF: artificial lysosomal fluid.