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Table 2 Zn concentration in BAL fluid and organs of shams and ZnO NP-exposed mice determined by ICP-MS

From: Toxicity assessment of zinc oxide nanoparticles using sub-acute and sub-chronic murine inhalation models

  Sub-acute study Sub-chronic study
Zn concentration Experimental group: Experimental group:
Shams (n = 6) ZnO 0 wk (n = 7) ZnO 3 wks (n = 6) Shams (n = 6) ZnO 0 wk (n = 8) ZnO 3 wks (n = 6)
BAL fluid, μg/L # 16 ± 2 73 ± 9*** 16 ± 2 48 ± 10 80 ± 23 42 ± 1
Blood, μg/L 4800 ± 123 4650 ± 131 4840 ± 157 5117 ± 189 5567 ± 42 4950 ± 250 ##
Lung, μg/g (dry wt) 123.3 ± 2.6 144.8 ± 6.9** 131.4 ± 13.7 109.7 ± 8.8 102.1 ± 4.4 109.6 ± 4.3
Heart, μg/g (dry wt) 121.8 ± 2.7 127.8 ± 6.0 112.6 ± 10.1 115.4 ± 4.4 150.9 ± 14.7* 124.1 ± 7.0
Liver, μg/g (dry wt) 155.5 ± 5.5 161.3 ± 4.4 153.2 ± 10.4 100.2 ± 5.3 111.2 ± 6.0 108.9 ± 8.4
Spleen, μg/g (dry wt) 108.6 ± 2.5 114.6 ± 4.2 111.6 ± 3.9 164.9 ± 33.6 277.6 ± 46.2 156.0 ± 23.3
Kidney, μg/g (dry wt) 97.8 ± 8.4 88.0 ± 4.0 85.9 ± 5.8 96.8 ± 7.9 110.8 ± 9.9 97.2 ± 7.0
Brain, μg/g (dry wt) 101.7 ± 4.4 102.7 ± 4.1 104.7 ± 4.1 47.9 ± 3.6 43.6 ± 2.6 43.6 ± 2.7
  1. Values are expressed as mean and SE; *p < 0.05, **p < 0.05, ***p < 0.001 significantly increased from shams.
  2. # BAL was not digested, Zn concentration represents mainly dissolved Zn ions in BAL fluid.
  3. ## n = 3.