Table 2 Zn concentration in BAL fluid and organs of shams and ZnO NP-exposed mice determined by ICP-MS
| Â | Sub-acute study | Sub-chronic study | ||||
|---|---|---|---|---|---|---|
Zn concentration | Experimental group: | Experimental group: | ||||
Shams (n = 6) | ZnO 0 wk (n = 7) | ZnO 3 wks (n = 6) | Shams (n = 6) | ZnO 0 wk (n = 8) | ZnO 3 wks (n = 6) | |
BAL fluid, μg/L # | 16 ± 2 | 73 ± 9*** | 16 ± 2 | 48 ± 10 | 80 ± 23 | 42 ± 1 |
Blood, μg/L | 4800 ± 123 | 4650 ± 131 | 4840 ± 157 | 5117 ± 189 | 5567 ± 42 | 4950 ± 250 ## |
Lung, μg/g (dry wt) | 123.3 ± 2.6 | 144.8 ± 6.9** | 131.4 ± 13.7 | 109.7 ± 8.8 | 102.1 ± 4.4 | 109.6 ± 4.3 |
Heart, μg/g (dry wt) | 121.8 ± 2.7 | 127.8 ± 6.0 | 112.6 ± 10.1 | 115.4 ± 4.4 | 150.9 ± 14.7* | 124.1 ± 7.0 |
Liver, μg/g (dry wt) | 155.5 ± 5.5 | 161.3 ± 4.4 | 153.2 ± 10.4 | 100.2 ± 5.3 | 111.2 ± 6.0 | 108.9 ± 8.4 |
Spleen, μg/g (dry wt) | 108.6 ± 2.5 | 114.6 ± 4.2 | 111.6 ± 3.9 | 164.9 ± 33.6 | 277.6 ± 46.2 | 156.0 ± 23.3 |
Kidney, μg/g (dry wt) | 97.8 ± 8.4 | 88.0 ± 4.0 | 85.9 ± 5.8 | 96.8 ± 7.9 | 110.8 ± 9.9 | 97.2 ± 7.0 |
Brain, μg/g (dry wt) | 101.7 ± 4.4 | 102.7 ± 4.1 | 104.7 ± 4.1 | 47.9 ± 3.6 | 43.6 ± 2.6 | 43.6 ± 2.7 |