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Table 1 Lung function measurements in 14-weeks old mice

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Sex

Female

Male

Genotype

WT

Cftr+/−

Cftr−/−

WT

Cftr+/−

Cftr−/−

N

8

11

8

8

8

8

BW (g)

22.8 ± 1.8

21.7 ± 1.4

22.5 ± 1.9

32.0 ± 2.4

31.2 ± 1.8

29.5 ± 3.3

TLC (mL)

1.23 ± 0.12

1.21 ± 0.10

1.18 ± 0.09

1.28 ± 0.08

1.29 ± 0.06

1.30 ± 0.14

TLC/BW (μL/g)

54.4 ± 3.7

56.0 ± 3.6

52.8 ± 3.6

40.2 ± 2.9

41.4 ± 3.0

44.4 ± 6.4

VD (μL)

224 ± 15

230 ± 11

225 ± 11

231 ± 19

232 ± 13

241 ± 28

VD/TLC (μL/mL)

184 ± 9

191 ± 11

191 ± 8

181 ± 18

183 ± 6

186 ± 18

C RS (μL/cm H 2 O)

51.2 ± 7.1

51.8 ± 5.8

46.7 ± 6.7

52.9 ± 4.2

54.1 ± 4.3

54.0 ± 8.0

C RS /TLC

41.2 ± 1.9

42.7 ± 1.5

39.3 ± 2.8*

41.2 ± 1.4

37.1 ± 1.5

41.5 ± 1.8

C L (μL/cm H 2 O)

70.7 ± 16

64.3 ± 11.9

57.3 ± 7.0*

71.9 ± 10.3

72.2 ± 7.0

64.2 ± 9.4

C L /TLC

57.1 ± 12.5

52.8 ± 6.5

48.4 ± 4.6*

55.8 ± 5.4

56.5 ± 3.8

49.5 ± 5.8

R (cm H 2 O/mL/s)

0.78 ± 0.20

0.84 ± 0.12

1.00 ± 0.21*+

0.84 ± 0.14

0.76 ± 0.18

0.93 ± 0.15

sR (cm H 2 O/s)

0.84 ± 0.40

1.01 ± 0.11

1.16 ± 0.19*

1.08 ± 0.18

0.98 ± 0.23

1.19 ± 0.13

D CO (μmol/min/hPa)

11.2 ± 2.8

11.9 ± 2.0

11.5 ± 1.5

15.9 ± 2.2

15.4 ± 2.0

15.3 ± 1.6

D CO /VA (μmol/min/hPa/mL VA)

9.3 ± 1.7

9.8 ± 1.5

10.3 ± 0.8

12.0 ± 0.8

11.6 ± 1.3

11.6 ± 1.1

D CO /VA (μmol/min/hPa/mL VA)

9.3 ± 1.7

9.8 ± 1.5

10.3 ± 0.8

12 ± 0.8

11.6 ± 1.3

11.6 ± 1.1

  1. Mean ± SD, WT: wild type, Cftr+/−: heterozygous Cftr mutants, Cftr−/−: homozygous Cftr mutants, BW: body weight, TLC: total lung capacity, VD: series (Fowler) dead space volume from helium expirogram, CRS: static compliance of respiratory system, CL: static lung compliance, R: respiratory system resistance, sR: specific respiratory system resistance (R × TLC), DCO: single breath diffusing capacity for carbon monoxide (CO), VA: alveolar volume determined from helium tracings of single breath diffusing capacity measurements, *: significant differences between aged matched wild type (WT) versus Cftr+/− or WT versus Cftr−/− , p < 0.05, +: significant differences between age matched Cftr+/− versus Cftr−/−, p < 0.05.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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