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Table 1 Lung function measurements in 14-weeks old mice

From: Biokinetics of nanoparticles and susceptibility to particulate exposure in a murine model of cystic fibrosis

Sex Female Male
Genotype WT Cftr+/− Cftr−/− WT Cftr+/− Cftr−/−
N 8 11 8 8 8 8
BW (g) 22.8 ± 1.8 21.7 ± 1.4 22.5 ± 1.9 32.0 ± 2.4 31.2 ± 1.8 29.5 ± 3.3
TLC (mL) 1.23 ± 0.12 1.21 ± 0.10 1.18 ± 0.09 1.28 ± 0.08 1.29 ± 0.06 1.30 ± 0.14
TLC/BW (μL/g) 54.4 ± 3.7 56.0 ± 3.6 52.8 ± 3.6 40.2 ± 2.9 41.4 ± 3.0 44.4 ± 6.4
VD (μL) 224 ± 15 230 ± 11 225 ± 11 231 ± 19 232 ± 13 241 ± 28
VD/TLC (μL/mL) 184 ± 9 191 ± 11 191 ± 8 181 ± 18 183 ± 6 186 ± 18
C RS (μL/cm H 2 O) 51.2 ± 7.1 51.8 ± 5.8 46.7 ± 6.7 52.9 ± 4.2 54.1 ± 4.3 54.0 ± 8.0
C RS /TLC 41.2 ± 1.9 42.7 ± 1.5 39.3 ± 2.8* 41.2 ± 1.4 37.1 ± 1.5 41.5 ± 1.8
C L (μL/cm H 2 O) 70.7 ± 16 64.3 ± 11.9 57.3 ± 7.0* 71.9 ± 10.3 72.2 ± 7.0 64.2 ± 9.4
C L /TLC 57.1 ± 12.5 52.8 ± 6.5 48.4 ± 4.6* 55.8 ± 5.4 56.5 ± 3.8 49.5 ± 5.8
R (cm H 2 O/mL/s) 0.78 ± 0.20 0.84 ± 0.12 1.00 ± 0.21*+ 0.84 ± 0.14 0.76 ± 0.18 0.93 ± 0.15
sR (cm H 2 O/s) 0.84 ± 0.40 1.01 ± 0.11 1.16 ± 0.19* 1.08 ± 0.18 0.98 ± 0.23 1.19 ± 0.13
D CO (μmol/min/hPa) 11.2 ± 2.8 11.9 ± 2.0 11.5 ± 1.5 15.9 ± 2.2 15.4 ± 2.0 15.3 ± 1.6
D CO /VA (μmol/min/hPa/mL VA) 9.3 ± 1.7 9.8 ± 1.5 10.3 ± 0.8 12.0 ± 0.8 11.6 ± 1.3 11.6 ± 1.1
D CO /VA (μmol/min/hPa/mL VA) 9.3 ± 1.7 9.8 ± 1.5 10.3 ± 0.8 12 ± 0.8 11.6 ± 1.3 11.6 ± 1.1
  1. Mean ± SD, WT: wild type, Cftr+/−: heterozygous Cftr mutants, Cftr−/−: homozygous Cftr mutants, BW: body weight, TLC: total lung capacity, VD: series (Fowler) dead space volume from helium expirogram, CRS: static compliance of respiratory system, CL: static lung compliance, R: respiratory system resistance, sR: specific respiratory system resistance (R × TLC), DCO: single breath diffusing capacity for carbon monoxide (CO), VA: alveolar volume determined from helium tracings of single breath diffusing capacity measurements, *: significant differences between aged matched wild type (WT) versus Cftr+/− or WT versus Cftr−/− , p < 0.05, +: significant differences between age matched Cftr+/− versus Cftr−/−, p < 0.05.