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Table 1 Delivered dose metrics

From: An integrated approach for the in vitro dosimetry of engineered nanomaterials

Material primary Primary particle size (nm) ρENM(g/cm3) ρEV(g/cm3) dH(nm) 96 well plate 384 well plate
      α (h−1) t90(h) α (h−1) t90(h)
Al2O3 14.7 3.97 1.81 57 0.0213 108 0.0317 72.7
CeO2 18.3 7.22 1.43 416 0.116 19.8 0.166 13.9
CoO 71.8 6.44 2.56 199 0.969 23.7 0.142 16.1
Cr2O3 193 5.22 2.21 358 0.246 9.37 0.343 6.71
Fe2O3 12.3 5.25 1.91 310 0.140 16.5 0.197 11.7
Fe3O4 12 5.17 1.46 274 0.0470 49.0 0.0751 30.7
Gd2O3 43.8 7.41 1.57 296 0.0730 31.5 0.112 20.6
Mn2O3 28.4 5.00 1.81 304 0.118 19.4 0.169 13.6
SiO2 13.5 2.65 1.30 40 0.0259 88.9 0.0406 56.7
TiO2 12.6 3.90 1.36 276 0.0366 62.9 0.0582 39.6
ZrO2 40.1 5.68 2.53 226 0.124 18.5 0.177 13.0
Printex (carbon black) 4.16 1.25 1.04 247 0.0126 183 0.0169 136
Carbon Nanohorns 20.3 1.25 1.02 261 0.0101 227 0.0139 166
VENGES SiO2 18.6 2.65 1.11 136 0.0138 166 0.0195 118
VENGES Fe2O3 27.6 5.245 1.52 380 0.117 19.6 0.167 13.8
VENGES CeO2-A 5.4 7.21 1.47 179 0.0288 80.0 0.0444 51.8
VENGES CeO2-B 27.9 7.21 1.62 181 0.0339 67.9 0.0525 43.8
VENGES CeO2-C 71.3 7.21 2.37 215 0.0991 23.2 0.145 15.9
EVONIK SiO2 14 2.65 1.15 227 0.0203 113 0.0297 77.6
Au Nanospheres 20* 19.3 17.7 42.2 0.0747 30.8 0.117 19.7
  1. ρENM: material density (g/cm3); ρEV: agglomerate effective density (g/cm3); dH: hydrodynamic diameter (nm); α: deposition fraction constant, (h−1); and t90: time for delivery of 90% of administered dose (h), for each ENM-media-concentration-well plate combination. Appropriate α can be used to accurately estimate the fraction of administered dose delivered to cells for any given exposure duration (see Equation 10).