From: Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats
Parameter | BMR (5%) | BMD (mg/kg bw, day) | CI (5% - 95%) | Statistical model |
---|---|---|---|---|
Body weight | ↓ | 2.85 | 1.84 – 5.72 | 2 |
Spleen weight | ↑ | 0.98 | 0.76 – 1.28 | 2 |
Thymus weight | ↓ | 1.31 | 0.76 – 3.03 | 2 |
RBC | ↑ | 2.64 | 2.04 – 3.62 | 2 |
RDW | ↑ | 1.79 | 1.50 – 2.02 | 5 |
HDW | ↑ | 1.89 | 1.28 – 2.48 | 5 |
MCV | ↓ | 1.95 | 1.77 – 2.11 | 5 |
MCH | ↓ | 1.76 | 1.39 – 1.91 | 5 |
MCHC | ↓ | 7.26 | 5.65 – 10.2 | 2 |
% neutrophils | ↑ | 1.23 | 0.69 – 3.76 | 2 |
% lymphocytes | ↓ | 4.15 | 2.57 – 10.0 | 2 |
% monocytes | ↑ | 0.69 | 0.48 – 1.01 | 2 |
% large unstained cells | ↑ | 3.74 | 1.24 – 4.31 | 3 |
% reticulocytes | ↑ | 1.23 | 0.85 – 1.96 | 2 |
# monocytes | ↑ | 0.59 | 0.35 – 1.16 | 2 |
Spleen cell number | ↑ | 1.03 | 0.74 – 1.51 | 2 |
% CD3 | ↑ | 1.41 | 1.09 – 1.88 | 2 |
% CD4 | ↑ | 1.47 | 1.11 – 2.04 | 2 |
% CD8 | ↑ | 1.11 | 0.73 – 1.95 | 2 |
% CD161a | ↑ | 0.89 | 0.62 – 1.34 | 2 |
CD3/CD45RA ratio | ↑ | 1.21 | 0.86 – 1.85 | 2 |
# CD3 | ↑ | 0.63 | 0.45 – 0.86 | 2 |
# CD4 | ↑ | 0.64 | 0.46 – 0.88 | 2 |
# CD8 | ↑ | 0.57 | 0.39 – 0.84 | 2 |
# CD161a | ↑ | 0.52 | 0.36 – 0.72 | 2 |
# CD45RA | ↑ | 1.10 | 0.68 – 2.23 | 2 |
KLH-IgG | ↓ | 0.73 | 0.40 – 1.63 | 2 |
KLH-IgM | ↑ | 5.28 | 3.64 – 6.01 | 3 |
Thymus IL-10 | ↓ | 1.17 | 0.58 – 4.53 | 2 |
Thymus IL-17 | ↓ | 2.79 | 1.47 – 6.60 | 2 |
Spleen IL-1β | ↑ | 2.74 | 1.57 – 6.94 | 2 |
Spleen IL-6 | ↑ | 2.22 | 1.21 – 6.20 | 2 |