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Table 1 Summary of BMDs BMR, benchmark response; BMD, benchmark dose; CI, 90% confidence interval, with BMDL (lowest 5% lower confidence bound) and BMDU (highest 95% upper confidence bound) indicated; statistical model: 2 (E2/H2), 3 (E3/H3), and 5 (E5/H5)

From: Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats

Parameter BMR (5%) BMD (mg/kg bw, day) CI (5% - 95%) Statistical model
Body weight 2.85 1.84 – 5.72 2
Spleen weight 0.98 0.76 – 1.28 2
Thymus weight 1.31 0.76 – 3.03 2
RBC 2.64 2.04 – 3.62 2
RDW 1.79 1.50 – 2.02 5
HDW 1.89 1.28 – 2.48 5
MCV 1.95 1.77 – 2.11 5
MCH 1.76 1.39 – 1.91 5
MCHC 7.26 5.65 – 10.2 2
% neutrophils 1.23 0.69 – 3.76 2
% lymphocytes 4.15 2.57 – 10.0 2
% monocytes 0.69 0.48 – 1.01 2
% large unstained cells 3.74 1.24 – 4.31 3
% reticulocytes 1.23 0.85 – 1.96 2
# monocytes 0.59 0.35 – 1.16 2
Spleen cell number 1.03 0.74 – 1.51 2
% CD3 1.41 1.09 – 1.88 2
% CD4 1.47 1.11 – 2.04 2
% CD8 1.11 0.73 – 1.95 2
% CD161a 0.89 0.62 – 1.34 2
CD3/CD45RA ratio 1.21 0.86 – 1.85 2
# CD3 0.63 0.45 – 0.86 2
# CD4 0.64 0.46 – 0.88 2
# CD8 0.57 0.39 – 0.84 2
# CD161a 0.52 0.36 – 0.72 2
# CD45RA 1.10 0.68 – 2.23 2
KLH-IgG 0.73 0.40 – 1.63 2
KLH-IgM 5.28 3.64 – 6.01 3
Thymus IL-10 1.17 0.58 – 4.53 2
Thymus IL-17 2.79 1.47 – 6.60 2
Spleen IL-1β 2.74 1.57 – 6.94 2
Spleen IL-6 2.22 1.21 – 6.20 2
  1. %, percentage; #, number