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Table 1 Summary of BMDs BMR, benchmark response; BMD, benchmark dose; CI, 90% confidence interval, with BMDL (lowest 5% lower confidence bound) and BMDU (highest 95% upper confidence bound) indicated; statistical model: 2 (E2/H2), 3 (E3/H3), and 5 (E5/H5)

From: Immunotoxicity of silver nanoparticles in an intravenous 28-day repeated-dose toxicity study in rats

Parameter

BMR (5%)

BMD (mg/kg bw, day)

CI (5% - 95%)

Statistical model

Body weight

2.85

1.84 – 5.72

2

Spleen weight

0.98

0.76 – 1.28

2

Thymus weight

1.31

0.76 – 3.03

2

RBC

2.64

2.04 – 3.62

2

RDW

1.79

1.50 – 2.02

5

HDW

1.89

1.28 – 2.48

5

MCV

1.95

1.77 – 2.11

5

MCH

1.76

1.39 – 1.91

5

MCHC

7.26

5.65 – 10.2

2

% neutrophils

1.23

0.69 – 3.76

2

% lymphocytes

4.15

2.57 – 10.0

2

% monocytes

0.69

0.48 – 1.01

2

% large unstained cells

3.74

1.24 – 4.31

3

% reticulocytes

1.23

0.85 – 1.96

2

# monocytes

0.59

0.35 – 1.16

2

Spleen cell number

1.03

0.74 – 1.51

2

% CD3

1.41

1.09 – 1.88

2

% CD4

1.47

1.11 – 2.04

2

% CD8

1.11

0.73 – 1.95

2

% CD161a

0.89

0.62 – 1.34

2

CD3/CD45RA ratio

1.21

0.86 – 1.85

2

# CD3

0.63

0.45 – 0.86

2

# CD4

0.64

0.46 – 0.88

2

# CD8

0.57

0.39 – 0.84

2

# CD161a

0.52

0.36 – 0.72

2

# CD45RA

1.10

0.68 – 2.23

2

KLH-IgG

0.73

0.40 – 1.63

2

KLH-IgM

5.28

3.64 – 6.01

3

Thymus IL-10

1.17

0.58 – 4.53

2

Thymus IL-17

2.79

1.47 – 6.60

2

Spleen IL-1β

2.74

1.57 – 6.94

2

Spleen IL-6

2.22

1.21 – 6.20

2

  1. %, percentage; #, number