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Figure 1 | Particle and Fibre Toxicology

Figure 1

From: Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes

Figure 1

Chronic exposure to SWCNT induces malignant transformation and CSC formation in bronchial epithelial cells. (A) Analysis of colony formation (left) and tumor spheres (right) in passage control BC cells, chronic SWCNT-exposed BSW cells, and lung cancer H460 cells after two weeks of culture. (B) Quantitative analysis of colony (top) and tumor spheres (bottom). (C) Analysis of side population (SP) in BC, BSW, and H460 cells in the presence or absence of fumitremorgin c (FTC) using FACS. SP cells (box) are determined by their disappearance in the presence of FTC. (D, E) Analysis of second-generation tumor spheres (D) and SP (E). Data are mean ± SD (n = 4). *p < 0.05 vs. control BC cells.

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Particle and Fibre Toxicology

ISSN: 1743-8977

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