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Figure 4 | Particle and Fibre Toxicology

Figure 4

From: Induction of stem-like cells with malignant properties by chronic exposure of human lung epithelial cells to single-walled carbon nanotubes

Figure 4

Aggressive tumor phenotypes of CSC-like cells derived from SWCNT-exposed lung epithelial cells. (A) Acquired apoptosis resistance of SP cells derived from malignant transformed BSW and lung cancer H460 cells to chemotherapy cisplatin (100 μM), doxorubicin (1 μM), antimycin A (30 μM), and etoposide (500 nM), compared to their respective non-SP (NSP) cells, as analyzed by Hoechst 33342 assay at 24 hours post-treatment. (B) Cell invasion (top) and migration (bottom) assays of SP and NSP cells derived from BSW and H460 cells, and the passage control BC cells, at 48 hours after incubation. Plots are relative invasion and migration level normalized to passage control BC cells. Representative fluorescence micrographs of invading and migrating cells are shown (right). Data are means ± SD (n = 4). * p < 0.05 vs. SP cells.

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