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Table 2 Histological analysis of lung tissue in control and welder patients

From: Role of metal oxide nanoparticles in histopathological changes observed in the lung of welders

 

Controls

Welders

P value

 

(n = 21)

(n = 21)

 

Siderophages

   

Presence (n patients)

10

17

0.024

Number (Mean semi-quantitative score ± SD)b

0.71 ± 0.90

1.57 ± 1.17

0.019

Ferruginous bodies (n patients)

   

Presence (n patients)

6

16

0.002

Number (Mean semi-quantitative score ± SD)b

0.43 ± 0.81

1.81 ± 1.57

0.002

Fibrotic lesions (Number of patients)

   

Peribronchiolar

16

20

ns

Perivascular

14

20

0.018

Paraseptal

8

10

ns

Alveolar

3

5

ns

Diffuse interstitial

6

5

ns

Pleural

4

2

ns

Severity of fibrosis a

   

(Mean semi-quantitative score ± SD)

   

Global

2.29 ± 1.59

3.91 ± 1.51

0.003

Peribronchiolar

1.10 ± 0.77

1.86 ± 0.85

0.005

Perivascular

1.05 ± 0.92

1.81 ± 0.81

0.010

Alveolar and peribronchiolar

1.57 ± 1.12

2.67 ± 1.16

0.004

Other respiratory lesions

   

Bronchiolectasis

16

13

ns

Bronchiolar metaplasia

2

0

ns

Bronchiolar dysplasia

1

5

ns

Respiratory Bronchiolitis – Intertitial Lung Disease

10

10

ns

Desquamative intertitial pneumonitis

12

9

ns

Endogenous Lipoid Pneumonitis

1

3

ns

  1. ns: not significant; SD: standard deviation.
  2. aSemi-quantitative score [4 classes = 0: absent; 1: rare; 2: frequent; 3: important]. Adapted from Roggli classification [54].
  3. bSemi-quantitative score [5 classes = 0: 0/slide; 1: < 5/slide; 2: 5 to 10/slide; 3: 10 to 50/slide ; 4: > 50/slide].