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Figure 5 | Particle and Fibre Toxicology

Figure 5

From: Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

Figure 5

Pulmonary bronchiolo-alveolar adenocarcinomas in MCA + MWCNT treated mice. A. The photomicrograph shows a right cardiac lung lobe of a MCA + MWCNT-treated mouse that contains a bronchiolo-alveolar adenocarcinoma (white arrow). A bronchiolo-alveolar adenoma (black arrow) is in the adjacent lung lobe. (2x). The magnification bar is 500 microns. B. The figure is a photomicrograph of a bronchiolo-alveolar adenocarcinoma in the right cardiac lobe of a mouse lung treated with MCA + MWCNT (20x). This infiltrative adenocarcinoma filled ~85% of the lobe on histologic cross section. The scale bar is 200 microns. C. The photomicrograph is a higher magnification of the bronchiolo-alveolar adenocarcinoma of the right cardiac lobe in figure B showing heterogeneous growth and pleomorphic cytologic features (40x). The scale bar is 50 microns. D. The photomicrograph shows a metastasis of the bronchiolo-alveolar adenocarcinoma in the right cardiac lobe of a mouse lung 17 months following treatment with MCA + MWCNT (40×). The arrow demonstrates a metastasis in a pulmonary vein. The scale bar is 50 microns.

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