IV study: Organ distribution ( μg/organ) of Ti on Day 2 after single IV dosing with NM-100, NM-102, NM-103 and NM-104 in male rats (LOD: 0.05 μg/g). A: liver, spleen and lungs, B: kidney, heart, brain, thymus, blood and testis. NM-100: brain < LOD. NM-102: brain < LOD. NM-103: blood and testis < LOD. NM-104: brain, blood and testis < LOD.