IV study: Organ distribution of Ti as percentage of administered dose at 24 h after the last dosing after single (i.e. Day 2) and repeated (i.e. Day 6) IV dosing with NM-100 (A), NM-102 (B), NM-103 (C), and NM-104 (D) in female rats. (LOD: 0.05 μg/g). Left: liver, spleen and lung, Right: kidney, heart, brain, thymus, blood and ovaria. NM-103: blood (single exposure) < LOD. NM-104: blood and brain (single exposure) < LOD.