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Table 3 Recovery of titanium for male and female rats in the summed investigated organs* as percentage of dose administered after single or repeated dosing

From: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

   Day 2/6** Day 14 Day 30 Day 90
Single      
NM-100 Male 75 ± 3 nd nd 55 ± 3
  Female 72 ± 8 nd nd 57 ± 1
NM-102 Male 64 ± 4 nd nd 52 ± 5
  Female 59 ± 6 nd nd 53 ± 1
NM-103 Male 86 ± 17 nd nd 91 ± 12
  Female 108 ± 8 nd nd 103 ± 12
NM-104 Male 95 ± 18 nd nd 109 ± 7
  Female 89 ± 5 nd nd 100 ± 4
Repeated      
NM-100 Male 71 ± 8 69 ± 4 70 ± 4 59 ± 5
  Female 73 ± 6 nd nd 61 ± 7
NM-102 Male 66 ± 14 69 ± 6 70 ± 3 54 ± 1
  Female 65 ± 8 nd nd 55 ± 1
NM-103 Male 95 ± 6 110 ± 21 96 ± 19 72 ± 13
  Female 88 ± 7 nd nd 84 ± 3
NM-104 Male 75 ± 5 99 ± 3 81 ± 10 77 ± 6
  Female 88 ± 10 nd nd 86 ± 4
  1. *liver, spleen, kidney, lung, heart, brain, thymus, blood, testes/ovaries.
  2. **Day 2 or day 6 corresponds to single or repeated dosing respectively.
  3. nd: not determined.