Table 3 Recovery of titanium for male and female rats in the summed investigated organs* as percentage of dose administered after single or repeated dosing
Day 2/6** | Day 14 | Day 30 | Day 90 | ||
|---|---|---|---|---|---|
Single | |||||
NM-100 | Male | 75 ± 3 | nd | nd | 55 ± 3 |
Female | 72 ± 8 | nd | nd | 57 ± 1 | |
NM-102 | Male | 64 ± 4 | nd | nd | 52 ± 5 |
Female | 59 ± 6 | nd | nd | 53 ± 1 | |
NM-103 | Male | 86 ± 17 | nd | nd | 91 ± 12 |
Female | 108 ± 8 | nd | nd | 103 ± 12 | |
NM-104 | Male | 95 ± 18 | nd | nd | 109 ± 7 |
Female | 89 ± 5 | nd | nd | 100 ± 4 | |
Repeated | |||||
NM-100 | Male | 71 ± 8 | 69 ± 4 | 70 ± 4 | 59 ± 5 |
Female | 73 ± 6 | nd | nd | 61 ± 7 | |
NM-102 | Male | 66 ± 14 | 69 ± 6 | 70 ± 3 | 54 ± 1 |
Female | 65 ± 8 | nd | nd | 55 ± 1 | |
NM-103 | Male | 95 ± 6 | 110 ± 21 | 96 ± 19 | 72 ± 13 |
Female | 88 ± 7 | nd | nd | 84 ± 3 | |
NM-104 | Male | 75 ± 5 | 99 ± 3 | 81 ± 10 | 77 ± 6 |
Female | 88 ± 10 | nd | nd | 86 ± 4 |