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Table 4 Basic pharmacokinetic parameters of titanium dioxide in different organs after 5 daily administrations of TiO 2 by the IV route

From: Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats

NM Organ β T1/2el Ct AUClast
   (/d) (d) (μg/g)* (μg d/g)**
NM-100 liver 0.0028 248 522.3 ± 23.34 (t = 6) 32790 ± 2306
NM-102 liver 0.0073 95 485.3 ± 62.13 (t = 6) 34682 ± 1195
NM-103 liver 0.0129 54 727.3 ± 64.72 (t = 14) 45919 ± 3684
NM-104 liver 0.0250 28 694.0 ± 10.82 (t = 14) 43491 ± 855
NM-100 kidney 0.0058 120 1.29 ± 0.09 (t = 6) 41 ± 4
NM-102 kidney 0.0047 146 1.45 ± 0.06 (t = 6) 69 ± 2
NM-103 kidney 0.0140 49 3.69 ± 0.19 (t = 6) 190 ± 19
NM-104 kidney 0.0013 531 2.46 ± 0.59 (t = 6) 178 ± 13
NM-100 lung 0.0153 45 54.67 ± 10.27 (t = 90) 4360 ± 381
NM-102 lung 0.0091 76 120.00 ± 19.22 (t = 14) 8733 ± 647
NM-103 lung 0.0072 96 130.67 ± 4.41 (t = 6) 7817 ± 672
NM-104 lung nc nc 55.02 ± 5.20 (t = 90) 3791 ± 187
NM-100 spleen 0.0011 650 536.01 ± 37.53 (t = 90) 41175 ± 1437
NM-102 spleen nc nc 827.33 ± 33.88 (t = 90) 45909 ± 1241
NM-103 spleen nc nc 1833.67 ± 578.34 (t = 90) 102710 ± 18670
NM-104 spleen nc nc 2221.667 ± 309.47 (t = 90) 130624 ± 9527
NM-100 heart 0.0048 146 0.81 ± 0.09 (t = 6) 39 ± 1
NM-102 heart 0.0050 140 0.81 ± 0.13 (t = 14) 48 ± 3
NM-103 heart 0.0029 237 1.35 ± 0.06 (t = 6) 85 ± 14
NM-104 heart nc nc 1.50 ± 0.26 (t = 90) 78 ± 10
  1. β = apparent elimination rate, T1/2el: apparent elimination half-life, Ct: highest concentration at time point t (day), AUClast: area under curve between the between 1st measured concentration and the last measured concentration, nc: not calculated.
  2. *P < 0.05 NM-100/NM-102 vs NM-103/NM-104 (for all tissues).
  3. **P < 0.05 NM-100 vs NM-103/NM-104 (for all tissues).