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Table 1 Percent of chromosome errors in SAEC cells following treatment with MWCNT orV 2 0 5

From: Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses

Dose MWCNT μg/cm2

Total % aneuploid cells

% loss of chromosome 1

% gain of chromosome 1

% loss of chromosome 4

% gain of chromosome 4

% gain of both chromosomes

Diluent

2.25 ± 1.0

1.0 ± 1.0%

1.0 ± 1.0%

1.25 ± 1.0%

1.0 ±1.0%

0

0.024

42 ±10*

2.0 ± 1.26

15.0 ± 2.0*

3.0 ± 1.26*

16.4 ± 2.0*

12.0 ± 3.0*

0.24

49 ±6.0

1.7 ± 0.7*

23.7 ± 5.0*

2.0 ± 10*

25 ± 4.0*

18 ± 6.0*

2.4

59.0 ± 6.0*

3.4 ± 0.8*

26.0 ± 3.0*

4.3 ± 1.2*

25 ± 10*

23 ± 5.0*

24

62 ±7.0*

7 ± 3.0%*

49.3 ± 4.0%*

8.0 ±3.0%*

53.3 ± 5%*

44 ± 5.0%*

Dose vanadium μg/cm2

      

0.31

69.0 ±7.0*

23.0 ± 5.0*

35.0 ± 9.0*

25.0 ± 11*

34.0 ± 7*

19.0 ± 6*

  1. *Statistically significant at p < .05.
  2. The distribution of the aneuploidy that was contributed by chromosome 1 and by chromosome 4 is detailed in the table as “Total % aneuploid cells”. The percent of cells with a gain in chromosome 1 and/or of chromosome 4 are indicated in the table under “Gain” of each chromosome. Cells with both chromosomes gained are indicated by “Gain of both chromosomes”. Cells with a loss of chromosome 1 and/or chromosome 4 are indicated in the table under “Loss” of each chromosome. *: p <0.05 of the treated cells compared to diluent control exposed cultures; ± standard deviation.
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Particle and Fibre Toxicology

ISSN: 1743-8977

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