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Table 1 Percent of chromosome errors in SAEC cells following treatment with MWCNT orV 2 0 5

From: Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses

Dose MWCNT μg/cm2 Total % aneuploid cells % loss of chromosome 1 % gain of chromosome 1 % loss of chromosome 4 % gain of chromosome 4 % gain of both chromosomes
Diluent 2.25 ± 1.0 1.0 ± 1.0% 1.0 ± 1.0% 1.25 ± 1.0% 1.0 ±1.0% 0
0.024 42 ±10* 2.0 ± 1.26 15.0 ± 2.0* 3.0 ± 1.26* 16.4 ± 2.0* 12.0 ± 3.0*
0.24 49 ±6.0 1.7 ± 0.7* 23.7 ± 5.0* 2.0 ± 10* 25 ± 4.0* 18 ± 6.0*
2.4 59.0 ± 6.0* 3.4 ± 0.8* 26.0 ± 3.0* 4.3 ± 1.2* 25 ± 10* 23 ± 5.0*
24 62 ±7.0* 7 ± 3.0%* 49.3 ± 4.0%* 8.0 ±3.0%* 53.3 ± 5%* 44 ± 5.0%*
Dose vanadium μg/cm2       
0.31 69.0 ±7.0* 23.0 ± 5.0* 35.0 ± 9.0* 25.0 ± 11* 34.0 ± 7* 19.0 ± 6*
  1. *Statistically significant at p < .05.
  2. The distribution of the aneuploidy that was contributed by chromosome 1 and by chromosome 4 is detailed in the table as “Total % aneuploid cells”. The percent of cells with a gain in chromosome 1 and/or of chromosome 4 are indicated in the table under “Gain” of each chromosome. Cells with both chromosomes gained are indicated by “Gain of both chromosomes”. Cells with a loss of chromosome 1 and/or chromosome 4 are indicated in the table under “Loss” of each chromosome. *: p <0.05 of the treated cells compared to diluent control exposed cultures; ± standard deviation.