The diagram illustrates the connections between the identified research priorities, and the implementation of the subsequent acquired knowledge and methods in the risk evaluation process. Each hexagon represents a priority research need, and each interface a logical relationship; with black hexagons representing NMs around the outside and the ITS modelling tools in the centre. Between the three priority research areas (Physicochemical, Exposure and Hazard ID) and the central ITS are the grouping/ranking approaches (bold hexagons) needed to streamline the data requirements. The blue arrows indicate the direction of research progress over time (from the perimeter of the diagram towards the core). The outputs of the ITS feed into the risk assessment frameworks at the bottom of the diagram.